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2016
7 Citations (Scopus)
Vanadium
Myelin Sheath
Iron
Oligodendroglia
Vanadates
2015
2 Citations (Scopus)

Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu

Liu, Y., Neely, E., Simmons, Z. & Connor, J. R., May 1 2015, In : Journal of Neuroscience Research. 93, 5, p. 766-776 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Apoptosis
Cell Survival
Motor Neurons
Pathologic Processes
60 Citations (Scopus)

A novel model for brain iron uptake: Introducing the concept of regulation

Simpson, I. A., Ponnuru, P., Klinger, M. E., Myers, R. L., Devraj, K., Coe, C. L., Lubach, G. R., Carruthers, A. & Connor, J. R., Jan 10 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 1, p. 48-57 10 p.

Research output: Contribution to journalArticle

Iron
Brain
Blood-Brain Barrier
Endothelial Cells
Transferrin
16 Citations (Scopus)

Comparative evaluation of nephrotoxicity and management by macrophages of intravenous pharmaceutical iron formulations

Connor, J. R., Zhang, X., Nixon, A. M., Webb, B. & Perno, J. R., May 14 2015, In : PloS one. 10, 5, e0125272.

Research output: Contribution to journalArticle

nephrotoxicity
Drug Compounding
Macrophages
macrophages
Iron
16 Citations (Scopus)
Alzheimer Disease
Iron
Neuroglia
Apoferritins
Amyloid Plaques
18 Citations (Scopus)

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

Zhao, L., Hadziahmetovic, M., Wang, C., Xu, X., Song, Y., Jinnah, H. A., Wodzinska, J., Iacovelli, J., Wolkow, N., Krajacic, P., Weissberger, A. C., Connelly, J., Spino, M., Lee, M. K., Connor, J., Giasson, B., Leah Harris, Z. & Dunaief, J. L., Dec 1 2015, In : Journal of neurochemistry. 135, 5, p. 958-974 17 p.

Research output: Contribution to journalArticle

Ceruloplasmin
Iron
Brain
Neurons
Neuroglia
9 Citations (Scopus)

Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death

Buranrat, B. & Connor, J. R., Nov 1 2015, In : Oncology reports. 34, 5, p. 2790-2796 7 p.

Research output: Contribution to journalArticle

Ferritins
Doxorubicin
Cell Death
Breast Neoplasms
Apoferritins
2 Citations (Scopus)

From adaption to death: Endoplasmic reticulum stress as a novel target of selective neurodegeneration?

Liu, Y. & Connor, J. R., Jan 1 2015, In : Neural Regeneration Research. 10, 9, p. 1397-1398 2 p.

Research output: Contribution to journalComment/debate

Endoplasmic Reticulum Stress
4 Citations (Scopus)

HFE polymorphisms affect survival of brain tumor patients

Lee, S. Y., Slagle-Webb, B., Sheehan, J. M., Zhu, J., Muscat, J. E., Glantz, M. & Connor, J. R., Jan 1 2015, In : Journal of neuro-oncology. 122, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Survival
Genotype
Iron
Neuroblastoma
14 Citations (Scopus)

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis

Meadowcroft, M. D., Mutic, N. J., Bigler, D. C., Wang, J. L., Simmons, Z., Connor, J. R. & Yang, Q. X., Mar 1 2015, In : Journal of Magnetic Resonance Imaging. 41, 3, p. 665-675 11 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Myelin Sheath
Astrocytes
Brain Death
87 Citations (Scopus)

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Schonberg, D. L., Miller, T. E., Wu, Q., Flavahan, W. A., Das, N. K., Hale, J. S., Hubert, C. G., Mack, S. C., Jarrar, A. M., Karl, R. T., Rosager, A. M., Nixon, A. M., Tesar, P. J., Hamerlik, P., Kristensen, B. W., Horbinski, C., Connor, J., Fox, P. L., Lathia, J. D. & Rich, J. N., Oct 12 2015, In : Cancer Cell. 28, 4, p. 441-455 15 p., 2152.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Glioblastoma
Stem Cells
Iron
Ferritins
8 Citations (Scopus)

Semaphorin4A is cytotoxic to oligodendrocytes and is elevated in microglia and multiple sclerosis

Leitner, D. F., Todorich, B., Zhang, X. & Connor, J. R., May 1 2015, In : ASN Neuro. 7, 3

Research output: Contribution to journalArticle

Oligodendroglia
Microglia
Multiple Sclerosis
Iron
Astrocytes
15 Citations (Scopus)

Serum ferritin is elevated in amyotrophic lateral sclerosis patients

Su, X. W., Clardy, S. L., Stephens, H. E., Simmons, Z. & Connor, J. R., Mar 1 2015, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 102-107 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Ferritins
Serum
Survival
Iron
22 Citations (Scopus)

The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease

Meadowcroft, M., Peters, D. G., Dewal, R. P., Connor, J. & Yang, Q., Mar 1 2015, In : NMR in Biomedicine. 28, 3, p. 297-305 9 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Magnetic resonance imaging
Alzheimer Disease
Iron
7 Citations (Scopus)

The effects of okra (Abelmoschus esculentus Linn.) on the cellular events associated with Alzheimer's disease in a stably expressed HFE neuroblastoma SH-SY5Y cell line

Mairuae, N., Connor, J. R., Lee, S. Y., Cheepsunthorn, P. & Tongjaroenbuangam, W., Aug 1 2015, In : Neuroscience letters. 603, p. 6-11 6 p.

Research output: Contribution to journalArticle

Abelmoschus
Neuroblastoma
Alzheimer Disease
Cell Line
Serine
3 Citations (Scopus)

The HFE genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice

Leitner, D. F., Stoute, J., Landmesser, M., Neely, E. & Connor, J., Oct 1 2015, In : International Journal for Parasitology. 45, 12, p. 797-808 12 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Iron
Genotype
Diet
Erythropoietin
54 Citations (Scopus)

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Peters, D. G., Connor, J. R. & Meadowcroft, M. D., Sep 1 2015, In : Neurobiology of Disease. 81, p. 49-65 17 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Iron
Amyloid Plaques
Amyloid
Brain
2014
113 Citations (Scopus)

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease)

Earley, C. J., Connor, J., Garcia-Borreguero, D., Jenner, P., Winkelman, J., Zee, P. C. & Allen, R., Nov 1 2014, In : Sleep Medicine. 15, 11, p. 1288-1301 14 p.

Research output: Contribution to journalReview article

Restless Legs Syndrome
Homeostasis
Iron
Brain
Animal Models
4 Citations (Scopus)

C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells

Ali-Rahmani, F., Huang, M. A., Schengrund, C. L., Connor, J. R. & Lee, S. Y., Feb 12 2014, In : PloS one. 9, 2, e88724.

Research output: Contribution to journalArticle

cholesterol metabolism
Neuroblastoma
Metabolism
Genes
Cholesterol
5 Citations (Scopus)

Characterization of a novel anti-cancer compound for astrocytomas

Lee, S. Y., Slagle-Webb, B., Rizk, E., Patel, A., Miller, P. A., Sung, S. S. & Connor, J. R., Sep 25 2014, In : PloS one. 9, 9, e108166.

Research output: Contribution to journalArticle

temozolomide
Astrocytoma
Tumors
neoplasms
cytotoxicity
11 Citations (Scopus)

Elevation in multiple serum inflammatory biomarkers predicts survival of pancreatic cancer patients with inoperable disease

Alkhateeb, A., Zubritsky, L., Kinsman, B., Leitzel, K., Campbell-Baird, C., Ali, S. M., Connor, J. & Lipton, A., Jun 2014, In : Journal of Gastrointestinal Cancer. 45, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

Ferritins
Pancreatic Neoplasms
C-Reactive Protein
Biomarkers
Survival
4 Citations (Scopus)
Theoretical Models
Iron
Population
Neoplasms
Genetic Polymorphisms
51 Citations (Scopus)

Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research

Su, X. W., Broach, J., Connor, J., Gerhard, G. S. & Simmons, Z., Jan 1 2014, In : Muscle and Nerve. 49, 6, p. 786-803 18 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Amyotrophic Lateral Sclerosis
Research
Clinical Trials
Exome
15 Citations (Scopus)

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis

Nandar, W., Neely, E. B., Simmons, Z. & Connor, J., Dec 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 12, p. 2413-2426 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Transgenic Mice
Disease Progression
Animal Models
Genotype
22 Citations (Scopus)

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment

Ali-Rahmani, F., Grigson-Kennedy, P. S., Lee, S., Neely, E., Connor, J. & Schengrund, C-L., Jan 1 2014, In : Neurobiology of Aging. 35, 6, p. 1511.e1-1511.e12

Research output: Contribution to journalArticle

Hemochromatosis
Cholesterol
Mutation
Apolipoprotein E4
Alzheimer Disease
26 Citations (Scopus)

HFE gene variants, iron, and lipids: A novel connection in Alzheimer's disease

Ali-Rahmani, F., Schengrund, C. L. & Connor, J. R., Jan 1 2014, In : Frontiers in Pharmacology. 5 JUL, 165.

Research output: Contribution to journalReview article

Lipid A
Neurodegenerative Diseases
Alzheimer Disease
Iron
Genes
13 Citations (Scopus)

Mechanism of metabolic stroke and spontaneous cerebral hemorrhage in glutaric aciduria type I

Zinnanti, W. J., Lazovic, J., Housman, C., Antonetti, D. A., Koeller, D. M., Connor, J. & Steinman, L., Jan 27 2014, In : Acta neuropathologica communications. 2, 1, 13.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Stroke
Corpus Striatum
Cerebral Veins
Occludin
10 Citations (Scopus)

The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype

Zhang, L., Ren, X., Cheng, Y., Liu, X., Allen, J. E., Zhang, Y., Yuan, Y., Huang, S. Y., Yang, W., Berg, A., Webb, B. S., Connor, J., Liu, C. G., Lu, Z., El-Deiry, W. S. & Yang, J. M., May 2014, In : Cancer Biology and Therapy. 15, 5, p. 602-611 10 p.

Research output: Contribution to journalArticle

Glioma
Stem Cells
Phenotype
temozolomide
Glioblastoma
2013
38 Citations (Scopus)

A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice

Nandar, W., Neely, E. B., Unger, E. & Connor, J., Jun 1 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 6, p. 729-741 13 p.

Research output: Contribution to journalArticle

Oxidative Stress
Iron
Apoferritins
Mutation
Brain
73 Citations (Scopus)

Application of fullerenes in nanomedicine: An update

Dellinger, A., Zhou, Z., Connor, J., Madhankumar, A., Pamujula, S., Sayes, C. M. & Kepley, C. L., Jul 2013, In : Nanomedicine. 8, 7, p. 1191-1208 18 p.

Research output: Contribution to journalReview article

Nanomedicine
Fullerenes
Medical nanotechnology
Magnetic resonance imaging
Contrast Media
37 Citations (Scopus)

Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis

Su, X. W., Simmons, Z., Mitchell, R. M., Kong, L., Stephens, H. E. & Connor, J. R., Dec 2013, In : JAMA neurology. 70, 12, p. 1505-1511 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Cerebrospinal Fluid
Biomarkers
Apoferritins
Hemochromatosis
60 Citations (Scopus)
Ferritins
Iron
Macrophages
Breast Neoplasms
Neoplasms
6 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Muscles
Genotype
Muscle Proteins
Superoxide Dismutase-1
25 Citations (Scopus)

Iron supplementation dose for perinatal iron deficiency differentially alters the neurochemistry of the frontal cortex and hippocampus in adult rats

Rao, R., Tkac, I., Unger, E. L., Ennis, K., Hurst, A., Schallert, T., Connor, J., Felt, B. & Georgieff, M. K., Jan 1 2013, In : Pediatric Research. 73, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Neurochemistry
Frontal Lobe
Hippocampus
Iron
Prefrontal Cortex
20 Citations (Scopus)

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease

Patton, S. M., Cho, Y. W., Clardy, T. W., Allen, R. P., Earley, C. J. & Connor, J. R., Jun 7 2013, In : Fluids and Barriers of the CNS. 10, 1, 20.

Research output: Contribution to journalArticle

Restless Legs Syndrome
Proteomics
Cerebrospinal Fluid
Proteins
prostaglandin R2 D-isomerase
101 Citations (Scopus)

The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis

Alkhateeb, A. A. & Connor, J., Dec 1 2013, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1836, 2, p. 245-254 10 p.

Research output: Contribution to journalReview article

Ferritins
Carcinogenesis
Inflammation
Neoplasms
Iron
2012
42 Citations (Scopus)

Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats

Unger, E. L., Hurst, A. R., Georgieff, M. K., Schallert, T., Rao, R., Connor, J. R., Kaciroti, N., Lozoff, B. & Felt, B., Nov 1 2012, In : Journal of Nutrition. 142, 11, p. 2040-2049 10 p.

Research output: Contribution to journalArticle

Iron
Diet
Iron-Deficiency Anemias
Brain
Weaning
21 Citations (Scopus)

Elevation in Inflammatory Serum Biomarkers Predicts Response to Trastuzumab-Containing Therapy

Alkhateeb, A. A., Leitzel, K., Ali, S. M., Campbell-Baird, C., Evans, M., Fuchs, E. M., Köstler, W. J., Lipton, A. & Connor, J., Dec 29 2012, In : PloS one. 7, 12, e51379.

Research output: Contribution to journalArticle

Biomarkers
biomarkers
Ferritins
C-Reactive Protein
therapeutics
68 Citations (Scopus)

Functional roles of transferrin in the brain

Leitner, D. F. & Connor, J. R., Mar 1 2012, In : Biochimica et Biophysica Acta - General Subjects. 1820, 3, p. 393-402 10 p.

Research output: Contribution to journalReview article

Transferrin
Brain
Iron
Choroid Plexus
Oligodendroglia

Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice

Carkaci-Salli, N., Battula, S., Wang, X., Connor, J. R. & Vrana, K. E., Aug 1 2012, In : Journal of Neuroscience Research. 90, 8, p. 1583-1588 6 p.

Research output: Contribution to journalArticle

Differentiation Antigens
Tyrosine 3-Monooxygenase
Thymocytes
Knockout Mice
Phosphoserine
9 Citations (Scopus)

Iron and ER stress in neurodegenerative disease

Liu, Y. & Connor, J. R., Aug 1 2012, In : BioMetals. 25, 4, p. 837-845 9 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Endoplasmic Reticulum Stress
neurodegenerative diseases
Neurodegenerative Diseases
endoplasmic reticulum
8 Citations (Scopus)

Maturational and aging effects on human brain apparent transverse relaxation

Wang, J., Shaffer, M. L., Eslinger, P. J., Sun, X., Weitekamp, C. W., Patel, M. M., Dossick, D., Gill, D. J., Connor, J. R. & Yang, Q. X., Feb 21 2012, In : PloS one. 7, 2, e31907.

Research output: Contribution to journalArticle

Brain
Aging of materials
brain
Red Nucleus
amygdala
22 Citations (Scopus)

Quantitative proteomic analyses of cerebrospinal fluid using itraq in a primate model of iron deficiency anemia

Patton, S. M., Coe, C. L., Lubach, G. R. & Connor, J. R., Oct 1 2012, In : Developmental Neuroscience. 34, 4, p. 354-365 12 p.

Research output: Contribution to journalArticle

Iron-Deficiency Anemias
Proteomics
Primates
Cerebrospinal Fluid
Iron
63 Citations (Scopus)

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS

Otto, M., Bowser, R., Turner, M., Berry, J., Brettschneider, J., Connor, J., Costa, J., Cudkowicz, M., Glass, J., Jahn, O., Lehnert, S., Malaspina, A., Parnetti, L., Petzold, A., Shaw, P., Sherman, A., Steinacker, P., Sßmuth, S., Teunissen, C., Tumani, H. & 2 others, Wuolikainen, A. & Ludolph, A., Jan 1 2012, In : Amyotrophic Lateral Sclerosis. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

Amyotrophic Lateral Sclerosis
Biomarkers
Early Diagnosis
2011
56 Citations (Scopus)

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice

Hadziahmetovic, M., Song, Y., Ponnuru, P., Iacovelli, J., Hunter, A., Haddad, N., Beard, J., Connor, J. R., Vaulont, S. & Dunaief, J. L., Jan 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 109-118 10 p.

Research output: Contribution to journalArticle

Hepcidins
Knockout Mice
Iron
Retina
Endothelial Cells
55 Citations (Scopus)

Detection of cancer cells in the cerebrospinal fluid: Current methods and future directions

Weston, C. L., Glantz, M. J. & Connor, J. R., Mar 3 2011, In : Fluids and Barriers of the CNS. 8, 1, 14.

Research output: Contribution to journalReview article

Cerebrospinal Fluid
Neoplasms
Lasers
Quantum Dots
Fluorescence Spectrometry
8 Citations (Scopus)

Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells

Ali-Rahmani, F., Hengst, J. A., Connor, J. R. & Schengrund, C. L., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1687-1696 10 p.

Research output: Contribution to journalArticle

Sphingolipids
Transcription
Neuroblastoma
Cells
Genes
7 Citations (Scopus)

Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues

Hall, E. C., Lee, S., Mairuae, N., Simmons, Z. & Connor, J., Aug 1 2011, In : Neurobiology of Aging. 32, 8, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

Serine
Glycogen Synthase Kinase 3
Phosphorylation
Iron
Oxidative Stress
56 Citations (Scopus)

Gender and iron genes may modify associations between brain iron and memory in healthy aging

Bartzokis, G., Lu, P. H., Tingus, K., Peters, D. G., Amar, C. P., Tishler, T. A., Finn, J. P., Villablanca, P., Altshuler, L. L., Mintz, J., Neely, E. & Connor, J. R., Jun 1 2011, In : Neuropsychopharmacology. 36, 7, p. 1375-1384 10 p.

Research output: Contribution to journalArticle

Iron
Brain
Genes
Transferrin
Basal Ganglia
46 Citations (Scopus)

Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents

Liu, X., Madhankumar, A. B., Slagle-Webb, B., Sheehan, J. M., Surguladze, N. & Connor, J. R., Mar 15 2011, In : Cancer Research. 71, 6, p. 2240-2249 10 p.

Research output: Contribution to journalArticle

Apoferritins
Liposomes
Small Interfering RNA
Carmustine
Glioma