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2018
4 Citations (Scopus)

Introduction to the thematic minireview series: Sixty plus years of polyamine research

Pegg, A. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18681-18692 12 p.

Research output: Contribution to journalReview article

Polyamines
Research
Biochemical Phenomena
Protozoa
Biochemistry
1 Citation (Scopus)

Mammalian dna repair enzymes

Pegg, A. E. & Bennett, R. A., Jan 1 2018, Enzymes of Nucleic Acid Synthesis and Modification: Volume 1: DNA Enzymes. CRC Press, p. 179-205 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
Repair
DNA
Enzymes
Chromatin
44 Citations (Scopus)

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Murray Stewart, T. & Pegg, A., Nov 1 2018, In : Nature Reviews Cancer. 18, 11, p. 681-695 15 p.

Research output: Contribution to journalReview article

Polyamines
Neoplasms
Therapeutics
Carcinogenesis
Clinical Trials

Unique Characteristics of the Parasite Polyamine Pathway

Pegg, A. E., Nov 6 2018, In : Structure. 26, 11, p. 1427-1429 3 p.

Research output: Contribution to journalShort survey

Eukaryotic Initiation Factors
Gene Duplication
Spermidine
Drug Design
Polyamines
2016
117 Citations (Scopus)

Functions of polyamines in mammals

Pegg, A. E., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14904-14912 9 p.

Research output: Contribution to journalReview article

Mammals
Spermidine
Polyamines
Spermine
Spermine Synthase
2014
77 Citations (Scopus)

The function of spermine

Pegg, A. E., Jan 1 2014, In : IUBMB Life. 66, 1, p. 8-18 11 p.

Research output: Contribution to journalReview article

Spermine
Spermine Synthase
Spermidine
Polyamines
Proteins
2013
10 Citations (Scopus)

Detection and characterization of 1,2-dibromoethane-derived dna crosslinks formed with O6-alkylguanine-DNA alkyltransferase

Chowdhury, G., Cho, S. H., Pegg, A. & Guengerich, F. P., Dec 2 2013, In : Angewandte Chemie - International Edition. 52, 49, p. 12879-12882 4 p.

Research output: Contribution to journalArticle

Ethylene Dibromide
DNA
O(6)-Methylguanine-DNA Methyltransferase
Mutagenesis
Chemical modification
27 Citations (Scopus)

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

Koomoa, D. L. T., Geerts, D., Lange, I., Koster, J., Pegg, A. E., Feith, D. J. & Bachmann, A. S., Apr 1 2013, In : International journal of oncology. 42, 4, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

Eflornithine
Neuroblastoma
Ornithine Decarboxylase
G1 Phase Cell Cycle Checkpoints
Phosphorylation
20 Citations (Scopus)

DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells

Tretyakova, N. Y., Michaelson-Richie, E. D., Gherezghiher, T. B., Kurtz, J., Ming, X., Wickramaratne, S., Campion, M., Kanugula, S., Pegg, A. & Campbell, C., May 7 2013, In : Biochemistry. 52, 18, p. 3171-3181 11 p.

Research output: Contribution to journalArticle

Mutagenesis
Cell death
Cell Death
Cells
DNA
16 Citations (Scopus)

Enhancing Human Spermine Synthase Activity by Engineered Mutations

Zhang, Z., Zheng, Y., Petukh, M., Pegg, A., Ikeguchi, Y. & Alexov, E., Feb 1 2013, In : PLoS computational biology. 9, 2, e1002924.

Research output: Contribution to journalArticle

Spermine Synthase
mutation
Mutation
amino acid
Amino Acids
5 Citations (Scopus)

Kinetics of O 6 -pyridyloxobutyl-2′-deoxyguanosine repair by human O 6 -alkylguanine DNA alkyltransferase

Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J. S., Pegg, A., Kanugula, S., Kassie, F. & Tretyakova, N., Jun 11 2013, In : Biochemistry. 52, 23, p. 4075-4088 14 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Deoxyguanosine
Repair
Nitrosamines
Kinetics
5 Citations (Scopus)

Role of aldehydes in the toxic and mutagenic effects of nitrosamines

Peterson, L. A., Urban, A. M., Vu, C. C., Cummings, M. E., Brown, L. C., Warmka, J. K., Li, L., Wattenberg, E. V., Patel, Y., Stram, D. O. & Pegg, A. E., Nov 4 2013, In : Chemical research in toxicology. 26, 10, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

Nitrosamines
Nitrosomethylurethane
Poisons
Aldehydes
Butanones
7 Citations (Scopus)

Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice

Feith, D. J., Pegg, A. E. & Fong, L. Y. Y., Mar 1 2013, In : Carcinogenesis. 34, 3, p. 570-576 7 p.

Research output: Contribution to journalArticle

Carcinogenesis
Zinc
Keratin-5
Neoplasms
nitrosobenzylmethylamine
84 Citations (Scopus)

Toxicity of polyamines and their metabolic products

Pegg, A. E., Dec 16 2013, In : Chemical research in toxicology. 26, 12, p. 1782-1800 19 p.

Research output: Contribution to journalReview article

Polyamines
Toxicity
Cellular Structures
Cells
Acrolein
2012
7 Citations (Scopus)

Characterization of transgenic mice with overexpression of spermidine synthase

Shi, C., Welsh, P. A., Sass-Kuhn, S., Wang, X., McCloskey, D. E., Pegg, A. E. & Feith, D. J., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 495-505 11 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Transgenic Mice
Spermidine
Polyamines
Spermine
1 Citation (Scopus)

Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography

Yamazaki, K., Ikeguchi, Y., Niwa, T., Hayashi, K., Iwaki, T., Ishii, I., Niitsu, M., Pegg, A. E. & Shirahata, A., 2012, In : Analytical Sciences. 28, 6, p. 621-624 4 p.

Research output: Contribution to journalArticle

Spermidine Synthase
High performance liquid chromatography
Spermine Synthase
Spermidine
Spermine
7 Citations (Scopus)

Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy

Giordano, E., Hillary, R. A., Vary, T. C., Pegg, A. E., Sumner, A. D., Caldarera, C. M., Zhang, X. Q., Song, J., Wang, J., Cheung, J. Y. & Shantz, L. M., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 507-518 12 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Ventricular Function
Cardiomegaly
Isoproterenol
Polyamines
20 Citations (Scopus)

Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells

Ishii, I., Ikeguchi, Y., Mano, H., Wada, M., Pegg, A. E. & Shirahata, A., Feb 1 2012, In : Amino Acids. 42, 2-3, p. 619-626 8 p.

Research output: Contribution to journalArticle

3T3-L1 Cells
Adipogenesis
Polyamines
Metabolism
Spermidine
2011
4 Citations (Scopus)

Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Šečkute, J., McCloskey, D. E., Thomas, H. J., Secrist, J. A., Pegg, A. & Ealick, S. E., Nov 1 2011, In : Protein Science. 20, 11, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

Spermidine Synthase
Putrescine
Polyamines
Spermine Synthase
Enzymes
44 Citations (Scopus)

Brain infarction correlates more closely with acrolein than with reactive oxygen species

Saiki, R., Park, H., Ishii, I., Yoshida, M., Nishimura, K., Toida, T., Tatsukawa, H., Kojima, S., Ikeguchi, Y., Pegg, A. E., Kashiwagi, K. & Igarashi, K., Jan 28 2011, In : Biochemical and Biophysical Research Communications. 404, 4, p. 1044-1049 6 p.

Research output: Contribution to journalArticle

Brain Infarction
Acrolein
Reactive Oxygen Species
Brain
Spermine
118 Citations (Scopus)

Current status of the polyamine research field.

Pegg, A. & Casero, R. A., May 24 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 3-35 33 p.

Research output: Contribution to journalReview article

Polyamines
Research
Drug Delivery Systems
Therapeutics
20 Citations (Scopus)

Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)

Lee, S. B., Park, J. H., Folk, J. E., Deck, J. A., Pegg, A. E., Sokabe, M., Fraser, C. S. & Park, M. H., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 205-213 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Acetylation
Acetyltransferases
Spermidine
Spermine
16 Citations (Scopus)

Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation

Green, R., Hanfrey, C. C., Elliott, K. A., Mccloskey, D. E., Wang, X., Kanugula, S., Pegg, A. E. & Michael, A. J., Aug 1 2011, In : Molecular Microbiology. 81, 4, p. 1109-1124 16 p.

Research output: Contribution to journalArticle

Proteobacteria
Diamines
Gene Fusion
Polyamines
Spermidine Synthase
8 Citations (Scopus)

Mass spectrometry based approach to study the kinetics of O 6-alkylguanine DNA alkyltransferase-mediated repair of O 6-pyridyloxobutyl-2′-deoxyguanosine adducts in DNA

Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S. & Tretyakova, N., Nov 21 2011, In : Chemical research in toxicology. 24, 11, p. 1966-1975 10 p.

Research output: Contribution to journalArticle

O(6)-Methylguanine-DNA Methyltransferase
Deoxyguanosine
DNA Adducts
Mass spectrometry
Mass Spectrometry
104 Citations (Scopus)
Alkyl and Aryl Transferases
Chemotherapy
DNA Repair
DNA Damage
Repair
5 Citations (Scopus)

O6-alkylguanine-DNA alkyltransferase

Pegg, A., Kanugula, S. & Loktionova, N. A., Dec 1 2011, Chemical Carcinogenesis. Penning, T. (ed.). p. 321-343 23 p. (Current Cancer Research; vol. 6).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA
Proteins
Alkylating Agents
DNA Repair
Carcinogens
1 Citation (Scopus)

Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O 4BF) and metabolite in a non-human primate model

Chuk, M. K., Cole, D. E., McCully, C., Loktionova, N. A., Pegg, A. E., Parker, R. J., Pauly, G., Widemann, B. C., Balis, F. M. & Fox, E., Jun 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 6, p. 1291-1297 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Metabolites
Primates
Cerebrospinal fluid
Plasmas
11 Citations (Scopus)

Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine

Pegg, A. E., Wang, X., Schwartz, C. E. & Mccloskey, D. E., Jan 1 2011, In : Biochemical Journal. 433, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

Spermine Synthase
S-Adenosylmethionine
Mammals
Polyamines
Nucleosides
19 Citations (Scopus)

Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

Schwartz, C. E., Wang, X., Stevenson, R. E. & Pegg, A., May 25 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 437-445 9 p.

Research output: Contribution to journalArticle

Spermine Synthase
Polyamines
Spermidine Synthase
Intellectual Disability
Spermidine
1 Citation (Scopus)

Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.

Wang, X. & Pegg, A., May 24 2011, In : Methods in molecular biology (Clifton, N.J.). 720, p. 159-170 12 p.

Research output: Contribution to journalArticle

Spermine Synthase
Spermine
Transgenic Mice
Putrescine
Spermidine
2010
7 Citations (Scopus)

Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells

Kalapila, A. G. & Pegg, A., Feb 3 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 684, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
Ethylene Dibromide
Mutation
CHO Cells
Hypoxanthine Phosphoribosyltransferase
4 Citations (Scopus)

Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity

Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E. & Ealick, S. E., Feb 17 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Thermotoga maritima
Substrate Specificity
Polyamines
Catalytic Domain
6 Citations (Scopus)

Effects of sequence context on O6-alkylguanine DNA alkyltransferase repair of O6-alkyl-deoxyguanosine adducts

Guza, R., Pegg, A. & Tretyakova, N., Jun 1 2010, Structural Biology of DNA Damage and Repair. American Chemical Society, p. 73-101 29 p. (ACS Symposium Series; vol. 1041).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Deoxyguanosine
DNA
Repair
Guanine
DNA sequences
21 Citations (Scopus)

Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases

Fang, Q., Kanugula, S., Tubbs, J. L., Tainer, J. A. & Pegg, A. E., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 8185-8195 11 p.

Research output: Contribution to journalArticle

Repair
DNA Repair
Nucleotides
Escherichia coli
Mutation
75 Citations (Scopus)

Spermine synthase

Pegg, A. & Michael, A. J., Jan 1 2010, In : Cellular and Molecular Life Sciences. 67, 1, p. 113-121 9 p.

Research output: Contribution to journalReview article

Spermine Synthase
Spermine
Catalytic Domain
Spermidine Synthase
Adenosylmethionine Decarboxylase
15 Citations (Scopus)

Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein

Aramini, J. M., Tubbs, J. L., Kanugula, S., Rossi, P., Ertekin, A., Maglaqui, M., Hamilton, K., Ciccosanti, C. T., Jiang, M., Xiao, R., Soong, T. T., Rost, B., Acton, T. B., Everett, J. K., Pegg, A. E., Tainer, J. A. & Montelione, G. T., Apr 30 2010, In : Journal of Biological Chemistry. 285, 18, p. 13736-13741 6 p.

Research output: Contribution to journalArticle

Alkyl and Aryl Transferases
DNA Repair
Repair
DNA
Proteins
25 Citations (Scopus)

Synthesis and characterization of an O6-2′-deoxyguanosine- alkyl-O6-2′-deoxyguanosine interstrand cross-link in a 5′-GNC motif and repair by human O6-alkylguanine-DNA alkyltransferase

McManus, F. P., Fang, Q., Booth, J. D. M., Noronha, A. M., Pegg, A. E. & Wilds, C. J., Oct 7 2010, In : Organic and Biomolecular Chemistry. 8, 19, p. 4414-4426 13 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Repair
deoxyribonucleic acid
DNA
synthesis
38 Citations (Scopus)

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

Geerts, D., Koster, J., Albert, D., Koomoa, D. L. T., Feith, D. J., Pegg, A. E., Volckmann, R., Caron, H., Versteeg, R. & Bachmann, A. S., May 1 2010, In : International Journal of Cancer. 126, 9, p. 2012-2024 13 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Polyamines
Neuroblastoma
Genes
Messenger RNA