Abstract
We designed a two-dimensional (2D) morphology-composition gradient panel, which has a gradient in surface morphology at constant chemical composition along its length and a gradient in surface chemical composition without change of surface morphology in the orthogonal direction. The panels, which exhibit a 2D gradient in surface wettability, were fabricated by thermolysis of parylene-C followed by oxygen-plasma treatment for various times. As a demonstration study, binding of three different biotinylated serum proteins (B-IgG, B-A, and B-TF) to the 2D panel was investigated. The 2D gradient panels will facilitate development of optimized binding surfaces for various biotechnological applications.
Original language | English (US) |
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Pages (from-to) | 1861-1866 |
Number of pages | 6 |
Journal | Materials Science and Engineering C |
Volume | 31 |
Issue number | 8 |
DOIs | |
State | Published - Dec 1 2011 |
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering