A biochemical analysis of thoracic neuroblastomas: A pediatric oncology group study

Stephen J. Shochat, Nancy L. Corbelletta, Mary Ann Repman, Cara Lynne Schengrund

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A biochemical analysis was performed on tumor tissuesfrom 20 patients who presented with thoracic neuroblastomas. Nine patients were under 1 year of age at the time of diagnosis, and 12 patients had stage A disease. Eighteen of the 20 patients are disease free with a mean follow-up of 51/2 years. The ganglioside composition of the tumor tissue was investigated, since these cell membrane components have been proposed to play a role in cell to cell interaction and may be altered on cell transformation. In addition, the ganglioside composition of the central nervous system changes with maturation. Previous studies in children with neuroblastoma have shown that tumor tissue containing more complex gangliosides is associated with a better prognosis. Neuroblastomas from patients with thoracic primaries were found to contain more complex gangliosides of the b series (GD1b, GT1b) and fewer monosialogangliosides, suggesting a more differentiated cellular composition. Tissue from one of the thoracic patients who died lacked GT1b. The absence of this ganglioside has proven to be an indicator of a poor prognosis. Four specimens contained no detectable GD2, which is thought to be a specific marker for neuroblastomas. These data suggest that the improved prognosis seen with thoracic neuroblas-tomas is due to a basic biologic difference within these tumors, and this finding should be taken into consideration when planning therapy.

Original languageEnglish (US)
Pages (from-to)660-664
Number of pages5
JournalJournal of pediatric surgery
Volume22
Issue number7
DOIs
StatePublished - Jul 1987

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'A biochemical analysis of thoracic neuroblastomas: A pediatric oncology group study'. Together they form a unique fingerprint.

Cite this