A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel

Jian Yang, Delara Motlagh, Antonio R. Webb, Guillermo A. Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A biphasic scaffold that recapitulates smooth muscle cell (SMC) compartmentalization in a tissue engineered construct was fabricated. A newly developed biodegradable elastomeric polyester, poly(diol-co-citrate) was investigated for use as a scaffold material. The biphasic scaffold consists of a solid, continuous phase enabling the formation of a monolayer of endothelia cells (EC) within the vessel lumen. The scaffold was subjected to various characterization, including burst pressure as well as co-culture with SMC and EC. The results suggest that a biphasic scaffold design based on poly(diol-co-citrate) is a viable strategy towards the engineering of small diameter blood vessels.

Original languageEnglish (US)
Title of host publication2004 AIChE Annual Meeting, Conference Proceedings
Pages8333-8335
Number of pages3
StatePublished - 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

Fingerprint

Blood vessels
Scaffolds (biology)
Tissue engineering
Scaffolds
Muscle
Polyesters
Monolayers
Cells
Tissue

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Yang, J., Motlagh, D., Webb, A. R., & Ameer, G. A. (2004). A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. In 2004 AIChE Annual Meeting, Conference Proceedings (pp. 8333-8335). [74c]
Yang, Jian ; Motlagh, Delara ; Webb, Antonio R. ; Ameer, Guillermo A. / A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. 2004 AIChE Annual Meeting, Conference Proceedings. 2004. pp. 8333-8335
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Yang, J, Motlagh, D, Webb, AR & Ameer, GA 2004, A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. in 2004 AIChE Annual Meeting, Conference Proceedings., 74c, pp. 8333-8335, 2004 AIChE Annual Meeting, Austin, TX, United States, 11/7/04.

A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. / Yang, Jian; Motlagh, Delara; Webb, Antonio R.; Ameer, Guillermo A.

2004 AIChE Annual Meeting, Conference Proceedings. 2004. p. 8333-8335 74c.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - A biphasic scaffold that recapitulates smooth muscle cell (SMC) compartmentalization in a tissue engineered construct was fabricated. A newly developed biodegradable elastomeric polyester, poly(diol-co-citrate) was investigated for use as a scaffold material. The biphasic scaffold consists of a solid, continuous phase enabling the formation of a monolayer of endothelia cells (EC) within the vessel lumen. The scaffold was subjected to various characterization, including burst pressure as well as co-culture with SMC and EC. The results suggest that a biphasic scaffold design based on poly(diol-co-citrate) is a viable strategy towards the engineering of small diameter blood vessels.

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Yang J, Motlagh D, Webb AR, Ameer GA. A biphasic elastomeric scaffold for tissue engineering a small-diameter blood vessel. In 2004 AIChE Annual Meeting, Conference Proceedings. 2004. p. 8333-8335. 74c