A bivariate functional mapping model for identifying haplotypes that control drug response for systolic and diastolic blood pressures

Min Lin, Rongling Wu, Julie Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

A bivariate functional mapping model has been proposed to detect haplotype-based DNA sequence variants that regulate the response curves of systolic and diastolic blood pressures (SBP and DBP) to a particular drug- This model capitalizes on the haplotype structure constructed by single nucleotide polymorphisms (SNPs) and incorporates the mathematical aspects of pharmacodynamic reactions into the estimation process, aimed to identify DNA sequence variants responsible for drug response. In this way, by estimating and testing the curve parameters that define drug response, many genetically and clinically meaningful hypotheses regarding the degree and pattern of the genetic control of SBP and DBP can be formulated, tested and disseminated. In a pharmacogenetic study composed of 107 subjects, our bivariate model has probed two haplotypes within the β2AR candidate gene that exert a significant effect on both SBP and DBP respond to dobutamine. With this candidate gene, two SNPs are genotyped, with allele Glyl6 (G) and Argl6 (A) at codon 16 and alleles Glu27 (G) and Gln27 (C) at codon 27, respectively. The significant haplotypes are [AC] for SBP and [GG| for DBP. This model provides a powerful tool for elucidating the genetic variants of drug response and ultimately designing personalized medications based on each patient's genetic makeup.

Original languageEnglish (US)
Title of host publicationProceedings of the Pacific Symposium on Biocomputing 2006, PSB 2006
Pages572-583
Number of pages12
Publication statusPublished - Dec 1 2006
Event11th Pacific Symposium on Biocomputing 2006, PSB 2006 - Maui, HI, United States
Duration: Jan 3 2006Jan 7 2006

Other

Other11th Pacific Symposium on Biocomputing 2006, PSB 2006
CountryUnited States
CityMaui, HI
Period1/3/061/7/06

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All Science Journal Classification (ASJC) codes

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Medicine(all)

Cite this

Lin, M., Wu, R., & Johnson, J. (2006). A bivariate functional mapping model for identifying haplotypes that control drug response for systolic and diastolic blood pressures. In Proceedings of the Pacific Symposium on Biocomputing 2006, PSB 2006 (pp. 572-583)