Heme-hyponitrites are intermediates that form at the bimetallic active sites of bacterial nitric oxide reductases. To probe a possible effect of the Fe-Fe distance on hyponitrite stability, we prepared a bridged bis-porphyrin Fe-hyponitrite compound, namely [(OEP-CH2)Fe]2(μ2,η1,η1-ONNO). Its υNO of 992 cm-1 (υ15NO of 976 cm-1) is close to the υNO of 983 cm-1 reported previously by us for the crystallographically characterized [(OEP)Fe]2(μ2,η1,η1-ONNO) compound. The bridged bis-porphyrin Fe-hyponitrite complex is unstable with respect to N2O production, supporting the role of the bis-Fe porphyrin system in hyponitrite conversion to N2O. The preparation and crystallographic determination of the bridging sulfato derivative is also reported.
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Cancer Research