A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite

Nan Xu, Erwin G. Abucayon, Douglas R. Powell, George B. Richter-Addo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Heme-hyponitrites are intermediates that form at the bimetallic active sites of bacterial nitric oxide reductases. To probe a possible effect of the Fe-Fe distance on hyponitrite stability, we prepared a bridged bis-porphyrin Fe-hyponitrite compound, namely [(OEP-CH2)Fe]2211-ONNO). Its υNO of 992 cm-115NO of 976 cm-1) is close to the υNO of 983 cm-1 reported previously by us for the crystallographically characterized [(OEP)Fe]2211-ONNO) compound. The bridged bis-porphyrin Fe-hyponitrite complex is unstable with respect to N2O production, supporting the role of the bis-Fe porphyrin system in hyponitrite conversion to N2O. The preparation and crystallographic determination of the bridging sulfato derivative is also reported.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalNitric Oxide - Biology and Chemistry
Volume52
DOIs
StatePublished - Jan 30 2016

Fingerprint

Biological Models
Porphyrins
Iron
Heme
Catalytic Domain
hyponitrite
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

Cite this

Xu, Nan ; Abucayon, Erwin G. ; Powell, Douglas R. ; Richter-Addo, George B. / A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite. In: Nitric Oxide - Biology and Chemistry. 2016 ; Vol. 52. pp. 16-20.
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abstract = "Heme-hyponitrites are intermediates that form at the bimetallic active sites of bacterial nitric oxide reductases. To probe a possible effect of the Fe-Fe distance on hyponitrite stability, we prepared a bridged bis-porphyrin Fe-hyponitrite compound, namely [(OEP-CH2)Fe]2(μ2,η1,η1-ONNO). Its υNO of 992 cm-1 (υ15NO of 976 cm-1) is close to the υNO of 983 cm-1 reported previously by us for the crystallographically characterized [(OEP)Fe]2(μ2,η1,η1-ONNO) compound. The bridged bis-porphyrin Fe-hyponitrite complex is unstable with respect to N2O production, supporting the role of the bis-Fe porphyrin system in hyponitrite conversion to N2O. The preparation and crystallographic determination of the bridging sulfato derivative is also reported.",
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A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite. / Xu, Nan; Abucayon, Erwin G.; Powell, Douglas R.; Richter-Addo, George B.

In: Nitric Oxide - Biology and Chemistry, Vol. 52, 30.01.2016, p. 16-20.

Research output: Contribution to journalArticle

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T1 - A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite

AU - Xu, Nan

AU - Abucayon, Erwin G.

AU - Powell, Douglas R.

AU - Richter-Addo, George B.

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AB - Heme-hyponitrites are intermediates that form at the bimetallic active sites of bacterial nitric oxide reductases. To probe a possible effect of the Fe-Fe distance on hyponitrite stability, we prepared a bridged bis-porphyrin Fe-hyponitrite compound, namely [(OEP-CH2)Fe]2(μ2,η1,η1-ONNO). Its υNO of 992 cm-1 (υ15NO of 976 cm-1) is close to the υNO of 983 cm-1 reported previously by us for the crystallographically characterized [(OEP)Fe]2(μ2,η1,η1-ONNO) compound. The bridged bis-porphyrin Fe-hyponitrite complex is unstable with respect to N2O production, supporting the role of the bis-Fe porphyrin system in hyponitrite conversion to N2O. The preparation and crystallographic determination of the bridging sulfato derivative is also reported.

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