A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite

Nan Xu, Erwin G. Abucayon, Douglas R. Powell, George B. Richter-Addo

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Abstract

Heme-hyponitrites are intermediates that form at the bimetallic active sites of bacterial nitric oxide reductases. To probe a possible effect of the Fe-Fe distance on hyponitrite stability, we prepared a bridged bis-porphyrin Fe-hyponitrite compound, namely [(OEP-CH2)Fe]2211-ONNO). Its υNO of 992 cm-115NO of 976 cm-1) is close to the υNO of 983 cm-1 reported previously by us for the crystallographically characterized [(OEP)Fe]2211-ONNO) compound. The bridged bis-porphyrin Fe-hyponitrite complex is unstable with respect to N2O production, supporting the role of the bis-Fe porphyrin system in hyponitrite conversion to N2O. The preparation and crystallographic determination of the bridging sulfato derivative is also reported.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalNitric Oxide - Biology and Chemistry
Volume52
DOIs
StatePublished - Jan 30 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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