A calcium-permeable cGMP-activated cation conductance in hippocampal neurons

Trese Leinders-Zufall, Hendrik Rosenboom, Colin J. Barnstable, Gordon M. Shepherd, Frank Zufall

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


WHOLE-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd2+. The Ca permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca2+. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca2+ fluxes in response to intracellular cGMP elevation.

Original languageEnglish (US)
Pages (from-to)1761-1765
Number of pages5
Issue number13
StatePublished - Sep 1995

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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