A case-control study of menstrual factors in relation to breast cancer risk in African-American women

Jessica S.B. Beiler, Kangmin Zhu, Sandra Hunter, Kathleen Payne-Wilks, Chanel L. Roland, Vernon Chinchilli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. No previous studies have systematically investigated menstrual factors in relation to the disease in African-American women. This case-control study is aimed to assess the relationship between menstrual factors and breast cancer in African-American women. Cases were 304 African-American women, aged 20-64 living in three Tennessee counties, diagnosed with breast cancer between 1995 and 1998. Controls were selected through random-digit dialing and frequency matched to cases (n=305). Phone interviews were conducted on menstrual factors-age at menarche, time to regularity, cycle length, flow length, age at menopause-and other risk factors. Logistic regression showed that compared to women with short cycle length (<28 days), women with average cycle length ≥28 had decreased risk of breast cancer (odds ratio (OR)=0.60, 95% confidence interval (CI), 0.38-0.94). Dose-response analyses showed decreasing risk with longer cycle length. Results by menopausal status revealed an inverse relationship was shown only in post-menopausal women. No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors.

Original languageEnglish (US)
Pages (from-to)930-938
Number of pages9
JournalJournal of the National Medical Association
Volume95
Issue number10
StatePublished - Oct 1 2003

Fingerprint

African Americans
Case-Control Studies
Breast Neoplasms
Menarche
Age Factors
Menopause
Estrogens
Logistic Models
Odds Ratio
Confidence Intervals
Interviews
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Beiler, Jessica S.B. ; Zhu, Kangmin ; Hunter, Sandra ; Payne-Wilks, Kathleen ; Roland, Chanel L. ; Chinchilli, Vernon. / A case-control study of menstrual factors in relation to breast cancer risk in African-American women. In: Journal of the National Medical Association. 2003 ; Vol. 95, No. 10. pp. 930-938.
@article{a587ead9b1fc4593aeb31badd40f2b1e,
title = "A case-control study of menstrual factors in relation to breast cancer risk in African-American women",
abstract = "Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. No previous studies have systematically investigated menstrual factors in relation to the disease in African-American women. This case-control study is aimed to assess the relationship between menstrual factors and breast cancer in African-American women. Cases were 304 African-American women, aged 20-64 living in three Tennessee counties, diagnosed with breast cancer between 1995 and 1998. Controls were selected through random-digit dialing and frequency matched to cases (n=305). Phone interviews were conducted on menstrual factors-age at menarche, time to regularity, cycle length, flow length, age at menopause-and other risk factors. Logistic regression showed that compared to women with short cycle length (<28 days), women with average cycle length ≥28 had decreased risk of breast cancer (odds ratio (OR)=0.60, 95{\%} confidence interval (CI), 0.38-0.94). Dose-response analyses showed decreasing risk with longer cycle length. Results by menopausal status revealed an inverse relationship was shown only in post-menopausal women. No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors.",
author = "Beiler, {Jessica S.B.} and Kangmin Zhu and Sandra Hunter and Kathleen Payne-Wilks and Roland, {Chanel L.} and Vernon Chinchilli",
year = "2003",
month = "10",
day = "1",
language = "English (US)",
volume = "95",
pages = "930--938",
journal = "Journal of the National Medical Association",
issn = "1943-4693",
publisher = "National Medical Association",
number = "10",

}

A case-control study of menstrual factors in relation to breast cancer risk in African-American women. / Beiler, Jessica S.B.; Zhu, Kangmin; Hunter, Sandra; Payne-Wilks, Kathleen; Roland, Chanel L.; Chinchilli, Vernon.

In: Journal of the National Medical Association, Vol. 95, No. 10, 01.10.2003, p. 930-938.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A case-control study of menstrual factors in relation to breast cancer risk in African-American women

AU - Beiler, Jessica S.B.

AU - Zhu, Kangmin

AU - Hunter, Sandra

AU - Payne-Wilks, Kathleen

AU - Roland, Chanel L.

AU - Chinchilli, Vernon

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. No previous studies have systematically investigated menstrual factors in relation to the disease in African-American women. This case-control study is aimed to assess the relationship between menstrual factors and breast cancer in African-American women. Cases were 304 African-American women, aged 20-64 living in three Tennessee counties, diagnosed with breast cancer between 1995 and 1998. Controls were selected through random-digit dialing and frequency matched to cases (n=305). Phone interviews were conducted on menstrual factors-age at menarche, time to regularity, cycle length, flow length, age at menopause-and other risk factors. Logistic regression showed that compared to women with short cycle length (<28 days), women with average cycle length ≥28 had decreased risk of breast cancer (odds ratio (OR)=0.60, 95% confidence interval (CI), 0.38-0.94). Dose-response analyses showed decreasing risk with longer cycle length. Results by menopausal status revealed an inverse relationship was shown only in post-menopausal women. No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors.

AB - Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. No previous studies have systematically investigated menstrual factors in relation to the disease in African-American women. This case-control study is aimed to assess the relationship between menstrual factors and breast cancer in African-American women. Cases were 304 African-American women, aged 20-64 living in three Tennessee counties, diagnosed with breast cancer between 1995 and 1998. Controls were selected through random-digit dialing and frequency matched to cases (n=305). Phone interviews were conducted on menstrual factors-age at menarche, time to regularity, cycle length, flow length, age at menopause-and other risk factors. Logistic regression showed that compared to women with short cycle length (<28 days), women with average cycle length ≥28 had decreased risk of breast cancer (odds ratio (OR)=0.60, 95% confidence interval (CI), 0.38-0.94). Dose-response analyses showed decreasing risk with longer cycle length. Results by menopausal status revealed an inverse relationship was shown only in post-menopausal women. No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors.

UR - http://www.scopus.com/inward/record.url?scp=0142094620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142094620&partnerID=8YFLogxK

M3 - Article

C2 - 14620704

AN - SCOPUS:0142094620

VL - 95

SP - 930

EP - 938

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

SN - 1943-4693

IS - 10

ER -