Abstract
We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. A concurrent core biopsy showed foci of spindled cell proliferation populated by osteoclast-like giant cells with stromal hemorrhage without evidence of metastatic carcinoma. The cytologic and histologic findings, in correlation with the clinical history, radiographic features, markedly increased parathyroid hormone levels and other serologic studies, were diagnostic of the reactive lesion seen in brown tumor of hyperparathyroidism secondary to chronic renal failure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | Diagnostic Cytopathology |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2018 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Histology
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A case report of brown tumor in a patient with chronic renal failure and renal cell carcinoma. / Liu, Yong Jun; Frauenhoffer, Elizabeth; Walker, Eric; Williams, Nicole.
In: Diagnostic Cytopathology, Vol. 46, No. 4, 01.04.2018, p. 355-361.Research output: Contribution to journal › Article
TY - JOUR
T1 - A case report of brown tumor in a patient with chronic renal failure and renal cell carcinoma
AU - Liu, Yong Jun
AU - Frauenhoffer, Elizabeth
AU - Walker, Eric
AU - Williams, Nicole
PY - 2018/4/1
Y1 - 2018/4/1
N2 - We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. A concurrent core biopsy showed foci of spindled cell proliferation populated by osteoclast-like giant cells with stromal hemorrhage without evidence of metastatic carcinoma. The cytologic and histologic findings, in correlation with the clinical history, radiographic features, markedly increased parathyroid hormone levels and other serologic studies, were diagnostic of the reactive lesion seen in brown tumor of hyperparathyroidism secondary to chronic renal failure.
AB - We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. A concurrent core biopsy showed foci of spindled cell proliferation populated by osteoclast-like giant cells with stromal hemorrhage without evidence of metastatic carcinoma. The cytologic and histologic findings, in correlation with the clinical history, radiographic features, markedly increased parathyroid hormone levels and other serologic studies, were diagnostic of the reactive lesion seen in brown tumor of hyperparathyroidism secondary to chronic renal failure.
UR - http://www.scopus.com/inward/record.url?scp=85036546462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036546462&partnerID=8YFLogxK
U2 - 10.1002/dc.23854
DO - 10.1002/dc.23854
M3 - Article
C2 - 29193813
AN - SCOPUS:85036546462
VL - 46
SP - 355
EP - 361
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 4
ER -