Abstract
Norepinephrine (NE) is a central nervous system neuromodulator that enhances the actions of other neurotransmitters such as gamma-aminobutyric acid and glutamate. Based on the Marr-Albus theories, Gilbert suggested that NE influences consolidation of cerebellar learning. NE depletion or blockade of postsynaptic noradrenergic receptors decreases the rate of learning in several cerebellar-dependent learning tasks. Loss of cerebellar beta-adrenergic receptor function correlates with a loss of function in related learning tasks. Interventions that improve beta-adrenergic receptor function also improve performance in cerebellum-dependent learning tasks. Thus, the authors propose that NE has a central role in the modulation of learning within the cerebellum.
Original language | English (US) |
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Pages (from-to) | 131-138 |
Number of pages | 8 |
Journal | Behavioral and cognitive neuroscience reviews |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2004 |
All Science Journal Classification (ASJC) codes
- Cognitive Neuroscience
- Behavioral Neuroscience