A central role for norepinephrine in the modulation of cerebellar learning tasks.

M. Claire Cartford, Thomas Gould, Paula C. Bickford

Research output: Contribution to journalReview article

18 Scopus citations


Norepinephrine (NE) is a central nervous system neuromodulator that enhances the actions of other neurotransmitters such as gamma-aminobutyric acid and glutamate. Based on the Marr-Albus theories, Gilbert suggested that NE influences consolidation of cerebellar learning. NE depletion or blockade of postsynaptic noradrenergic receptors decreases the rate of learning in several cerebellar-dependent learning tasks. Loss of cerebellar beta-adrenergic receptor function correlates with a loss of function in related learning tasks. Interventions that improve beta-adrenergic receptor function also improve performance in cerebellum-dependent learning tasks. Thus, the authors propose that NE has a central role in the modulation of learning within the cerebellum.

Original languageEnglish (US)
Pages (from-to)131-138
Number of pages8
JournalBehavioral and cognitive neuroscience reviews
Issue number2
Publication statusPublished - Jun 2004


All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Behavioral Neuroscience

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