A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC

Hridayabhiranjan Shukla, Gerald A. Gillespie, Rakesh Srivastava, Francis Collins, Michael J. Chorney

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

By the combination of cosmid cloning, chromosomal jumping, and pulsed-field gel electrophoresis (PFGE), we have fine-mapped the HLA-A subregion of the human major histocompatibility complex (MHC). Through the isolation of a class I jumping clone, the Qa-like HLA-G class I gene has been placed within 100 kb of HLA-H. The tight physical linkage of these class I genes has been further supported by hybridizing PFGE blots with locus-specific probes. It has been found that both of the above class I genes are linked to HLA-A, with HLA-H residing no more than 200 kb from the HLA-A gene. These data support the possible existence of a Qa-like subregion composed of nonclassical HLA class I genes within the human MHC linked telomerically to the HLA-A locus.

Original languageEnglish (US)
Pages (from-to)905-914
Number of pages10
JournalGenomics
Volume10
Issue number4
DOIs
StatePublished - Aug 1991

All Science Journal Classification (ASJC) codes

  • Genetics

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