A collision tumor: Primary central nervous system B-cell lymphoma and anaplastic astrocytoma

Indu Basil, Kun Ru, Cunfeng Pu, Jan Silverman, Katherine Jasnosz

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A collision tumor in the central nervous system (CNS) is a rare entity. We report a case of a collision tumor with primary CNS lymphoma and astrocytoma in an otherwise healthy young male and the diagnostic challenge associated with it. The tumor showed 2 histologic patterns. The predominant component consisted of anaplastic astrocytoma with gemistocytic appearance, and the lymphoma cells were kappa restricted B cells with variable cell sizes and some plasmacytoid differentiation. In situ hybridization demonstrated that the lymphoma cells were Epstein-Barr virus (EBV) positive. The patient was neurologically asymptomatic for 2 and half years following surgery, chemotherapy, and radiation.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalLaboratory Medicine
Volume42
Issue number6
DOIs
StatePublished - Jul 21 2011

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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