A collision tumor

Primary central nervous system B-cell lymphoma and anaplastic astrocytoma

Indu Basil, Kun Ru, Cunfeng Pu, Jan Silverman, Katherine Jasnosz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A collision tumor in the central nervous system (CNS) is a rare entity. We report a case of a collision tumor with primary CNS lymphoma and astrocytoma in an otherwise healthy young male and the diagnostic challenge associated with it. The tumor showed 2 histologic patterns. The predominant component consisted of anaplastic astrocytoma with gemistocytic appearance, and the lymphoma cells were kappa restricted B cells with variable cell sizes and some plasmacytoid differentiation. In situ hybridization demonstrated that the lymphoma cells were Epstein-Barr virus (EBV) positive. The patient was neurologically asymptomatic for 2 and half years following surgery, chemotherapy, and radiation.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalLaboratory Medicine
Volume42
Issue number6
DOIs
StatePublished - Jul 21 2011

Fingerprint

Central Nervous System Neoplasms
Astrocytoma
Neurology
B-Cell Lymphoma
Tumors
Lymphoma
Cells
Chemotherapy
Human Herpesvirus 4
Cell Size
Viruses
Surgery
In Situ Hybridization
Neoplasms
B-Lymphocytes
Central Nervous System
Radiation
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Basil, Indu ; Ru, Kun ; Pu, Cunfeng ; Silverman, Jan ; Jasnosz, Katherine. / A collision tumor : Primary central nervous system B-cell lymphoma and anaplastic astrocytoma. In: Laboratory Medicine. 2011 ; Vol. 42, No. 6. pp. 324-328.
@article{393e093c84c943b6b56ed65a7a4b5f42,
title = "A collision tumor: Primary central nervous system B-cell lymphoma and anaplastic astrocytoma",
abstract = "A collision tumor in the central nervous system (CNS) is a rare entity. We report a case of a collision tumor with primary CNS lymphoma and astrocytoma in an otherwise healthy young male and the diagnostic challenge associated with it. The tumor showed 2 histologic patterns. The predominant component consisted of anaplastic astrocytoma with gemistocytic appearance, and the lymphoma cells were kappa restricted B cells with variable cell sizes and some plasmacytoid differentiation. In situ hybridization demonstrated that the lymphoma cells were Epstein-Barr virus (EBV) positive. The patient was neurologically asymptomatic for 2 and half years following surgery, chemotherapy, and radiation.",
author = "Indu Basil and Kun Ru and Cunfeng Pu and Jan Silverman and Katherine Jasnosz",
year = "2011",
month = "7",
day = "21",
doi = "10.1309/LMR93DQ1LYHOJUQB",
language = "English (US)",
volume = "42",
pages = "324--328",
journal = "Laboratory Medicine",
issn = "0007-5027",
publisher = "American Society of Clinical Pathologists",
number = "6",

}

A collision tumor : Primary central nervous system B-cell lymphoma and anaplastic astrocytoma. / Basil, Indu; Ru, Kun; Pu, Cunfeng; Silverman, Jan; Jasnosz, Katherine.

In: Laboratory Medicine, Vol. 42, No. 6, 21.07.2011, p. 324-328.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A collision tumor

T2 - Primary central nervous system B-cell lymphoma and anaplastic astrocytoma

AU - Basil, Indu

AU - Ru, Kun

AU - Pu, Cunfeng

AU - Silverman, Jan

AU - Jasnosz, Katherine

PY - 2011/7/21

Y1 - 2011/7/21

N2 - A collision tumor in the central nervous system (CNS) is a rare entity. We report a case of a collision tumor with primary CNS lymphoma and astrocytoma in an otherwise healthy young male and the diagnostic challenge associated with it. The tumor showed 2 histologic patterns. The predominant component consisted of anaplastic astrocytoma with gemistocytic appearance, and the lymphoma cells were kappa restricted B cells with variable cell sizes and some plasmacytoid differentiation. In situ hybridization demonstrated that the lymphoma cells were Epstein-Barr virus (EBV) positive. The patient was neurologically asymptomatic for 2 and half years following surgery, chemotherapy, and radiation.

AB - A collision tumor in the central nervous system (CNS) is a rare entity. We report a case of a collision tumor with primary CNS lymphoma and astrocytoma in an otherwise healthy young male and the diagnostic challenge associated with it. The tumor showed 2 histologic patterns. The predominant component consisted of anaplastic astrocytoma with gemistocytic appearance, and the lymphoma cells were kappa restricted B cells with variable cell sizes and some plasmacytoid differentiation. In situ hybridization demonstrated that the lymphoma cells were Epstein-Barr virus (EBV) positive. The patient was neurologically asymptomatic for 2 and half years following surgery, chemotherapy, and radiation.

UR - http://www.scopus.com/inward/record.url?scp=79960395748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960395748&partnerID=8YFLogxK

U2 - 10.1309/LMR93DQ1LYHOJUQB

DO - 10.1309/LMR93DQ1LYHOJUQB

M3 - Article

VL - 42

SP - 324

EP - 328

JO - Laboratory Medicine

JF - Laboratory Medicine

SN - 0007-5027

IS - 6

ER -