A comparison of clinical and research practices in measuring cerebral perfusion pressure: A literature review and practitioner survey

Jennifer A. Kosty, Peter D. Leroux, Joshua Levine, Soojin Park, Monisha A. Kumar, Suzanne Frangos, Eileen Maloney-Wilensky, W. Andrew Kofke

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Background: Our objective was to determine whether there is variability in the foundational literature and across centers in how mean arterial blood pressure is measured to calculate cerebral perfusion pressure. Methods: We reviewed foundational literature and sent an e-mail survey to members of the Neurocritical Care Society. Results: Of 32 articles reporting cerebral perfusion pressure data, the reference point for mean arterial blood pressure was identified in 16: 10 heart and 6 midbrain. The overall survey response rate was 14.3%. Responses from 31 of 34 (91%) United Council for Neurologic Subspecialties fellowship-accredited Neurointensive Care Units indicated the reference point was most often the heart (74%), followed by the midbrain (16%). Conflicting answers were received from 10%. Conclusions: There is substantive heterogeneity in both research reports and clinical practice in how mean arterial blood pressure is measured to determine cerebral perfusion pressure.

Original languageEnglish (US)
Pages (from-to)694-698
Number of pages5
JournalAnesthesia and analgesia
Issue number3
StatePublished - Sep 2013

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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