A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

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Abstract

Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers. Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P<0.01). There were no differences in model fit between CR-and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P<0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalBiomarkers
Volume16
Issue number3
DOIs
StatePublished - May 1 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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