Abstract
Patients with a small fiber neuropathy often are difficult to diagnose. They frequently undergo various diagnostic studies including quantitative sensory testing (QST) and skin biopsy. We wanted to determine if there was a correlation between findings on a QST study to that of a skin biopsy. Twenty patients were prospectively studied. Nine had an abnormal skin biopsy. Thirteen patients had an abnormal QST. Seven of the nine patients with an abnormal skin biopsy had an abnormal QST. Assuming that skin biopsy is the gold standard for identification of small fiber neuropathies, the sensitivity of QST for detection of such neuropathies is high, provided that both cold and warm sensation thresholds are studied. However, the specificity of QST for small fiber neuropathies is low (46%).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-132 |
| Number of pages | 4 |
| Journal | Journal of Clinical Neuromuscular Disease |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2003 |
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All Science Journal Classification (ASJC) codes
- Clinical Neurology
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A comparison of quantitative sensory testing with skin biopsy in small fiber neuropathy. / Scott, Kevin; Simmons, Zachary; Kothari, Milind J.
In: Journal of Clinical Neuromuscular Disease, Vol. 4, No. 3, 01.03.2003, p. 129-132.Research output: Contribution to journal › Article
TY - JOUR
T1 - A comparison of quantitative sensory testing with skin biopsy in small fiber neuropathy
AU - Scott, Kevin
AU - Simmons, Zachary
AU - Kothari, Milind J.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Patients with a small fiber neuropathy often are difficult to diagnose. They frequently undergo various diagnostic studies including quantitative sensory testing (QST) and skin biopsy. We wanted to determine if there was a correlation between findings on a QST study to that of a skin biopsy. Twenty patients were prospectively studied. Nine had an abnormal skin biopsy. Thirteen patients had an abnormal QST. Seven of the nine patients with an abnormal skin biopsy had an abnormal QST. Assuming that skin biopsy is the gold standard for identification of small fiber neuropathies, the sensitivity of QST for detection of such neuropathies is high, provided that both cold and warm sensation thresholds are studied. However, the specificity of QST for small fiber neuropathies is low (46%).
AB - Patients with a small fiber neuropathy often are difficult to diagnose. They frequently undergo various diagnostic studies including quantitative sensory testing (QST) and skin biopsy. We wanted to determine if there was a correlation between findings on a QST study to that of a skin biopsy. Twenty patients were prospectively studied. Nine had an abnormal skin biopsy. Thirteen patients had an abnormal QST. Seven of the nine patients with an abnormal skin biopsy had an abnormal QST. Assuming that skin biopsy is the gold standard for identification of small fiber neuropathies, the sensitivity of QST for detection of such neuropathies is high, provided that both cold and warm sensation thresholds are studied. However, the specificity of QST for small fiber neuropathies is low (46%).
UR - http://www.scopus.com/inward/record.url?scp=1642444254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1642444254&partnerID=8YFLogxK
U2 - 10.1097/00131402-200303000-00006
DO - 10.1097/00131402-200303000-00006
M3 - Article
AN - SCOPUS:1642444254
VL - 4
SP - 129
EP - 132
JO - Journal of Clinical Neuromuscular Disease
JF - Journal of Clinical Neuromuscular Disease
SN - 1522-0443
IS - 3
ER -