A Comprehensive Study of Ultrasound Transducer Characteristics in Microscopic Ultrasound Neuromodulation

Hesam Sadeghi Gougheri, Ajay Dangi, Sri Rajasekhar Kothapalli, Mehdi Kiani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In order to improve the spatial resolution of transcranial focused ultrasound stimulation (tFUS), we have recently proposed microscopic ultrasound stimulation (μUS). In μUS, either an electronically phased array of ultrasound transducers or several millimeter-sized focused transducers are placed on the brain surface or sub-millimeter-sized transducers are implanted inside the brain tissue to steer and deliver a focused ultrasound pressure directly to the neural target. A key element in both tFUS and μUS is the ultrasound transducer that converts electrical power to acoustic pressure. The literature lacks a comprehensive study (in a quantitative manner) of the transducer characteristics, such as dimension, focusing, acoustic matching, backing material, and sonication frequency (fp), in the μUS. This paper studies the impact of these design parameters on the acoustic beam profile of millimeter-sized transducers with the emphasis on the stimulation spatial resolution and energy efficiency, which is defined as the μUS figure-of-merit (FoM). For this purpose, disc-shaped focused and unfocused piezoelectric (PZT-5A) transducers with different dimension (diameter, thickness), backing material (PCB, air) and acoustic matching in the frequency range of 2.2-9.56 MHz were fabricated. Our experimental studies with both water and sheep brain phantom medium demonstrate that acoustically matched focused transducers with high quality factor are desirable for μUS, as they provide fine spatial resolution and high acoustic intensities with low input electrical power levels (i.e., high FoM).

Original languageEnglish (US)
Article number8734697
Pages (from-to)835-847
Number of pages13
JournalIEEE Transactions on Biomedical Circuits and Systems
Volume13
Issue number5
DOIs
StatePublished - Oct 2019

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Transducers
Ultrasonics
Acoustics
Brain
Acoustic intensity
Sonication
Polychlorinated biphenyls
Energy efficiency
Tissue
Air

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

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abstract = "In order to improve the spatial resolution of transcranial focused ultrasound stimulation (tFUS), we have recently proposed microscopic ultrasound stimulation (μUS). In μUS, either an electronically phased array of ultrasound transducers or several millimeter-sized focused transducers are placed on the brain surface or sub-millimeter-sized transducers are implanted inside the brain tissue to steer and deliver a focused ultrasound pressure directly to the neural target. A key element in both tFUS and μUS is the ultrasound transducer that converts electrical power to acoustic pressure. The literature lacks a comprehensive study (in a quantitative manner) of the transducer characteristics, such as dimension, focusing, acoustic matching, backing material, and sonication frequency (fp), in the μUS. This paper studies the impact of these design parameters on the acoustic beam profile of millimeter-sized transducers with the emphasis on the stimulation spatial resolution and energy efficiency, which is defined as the μUS figure-of-merit (FoM). For this purpose, disc-shaped focused and unfocused piezoelectric (PZT-5A) transducers with different dimension (diameter, thickness), backing material (PCB, air) and acoustic matching in the frequency range of 2.2-9.56 MHz were fabricated. Our experimental studies with both water and sheep brain phantom medium demonstrate that acoustically matched focused transducers with high quality factor are desirable for μUS, as they provide fine spatial resolution and high acoustic intensities with low input electrical power levels (i.e., high FoM).",
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A Comprehensive Study of Ultrasound Transducer Characteristics in Microscopic Ultrasound Neuromodulation. / Gougheri, Hesam Sadeghi; Dangi, Ajay; Kothapalli, Sri Rajasekhar; Kiani, Mehdi.

In: IEEE Transactions on Biomedical Circuits and Systems, Vol. 13, No. 5, 8734697, 10.2019, p. 835-847.

Research output: Contribution to journalArticle

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