A Convenient Synthesis of trans-3’-Hydroxycotinine, a Major Nicotine Metabolite Found in the Urine of Tobacco Users

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trans-3’-Hydroxycotinine is a major urinary metabolite of nicotine in smokers, but no straightforward method is available for its synthesis. A simple method was developed for preparation of trans-3’-hydroxycotinine from cotinine in two steps by using NaN[(CH3)3Si]2 and dibenzyl peroxydicarbonate, followed by base-catalyzed hydrolysis.

Original languageEnglish (US)
Pages (from-to)47-48
Number of pages2
JournalChemical research in toxicology
Issue number1
Publication statusPublished - Jan 1 1990


All Science Journal Classification (ASJC) codes

  • Toxicology

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