TY - JOUR
T1 - A coupled reaction–diffusion–strain model predicts cranial vault formation in development and disease
AU - Lee, Chanyoung
AU - Richtsmeier, Joan T.
AU - Kraft, Reuben H.
N1 - Funding Information:
Computations for this research were performed on the Pennsylvania State University’s Institute for CyberScience Advanced CyberInfrastructure (ICS-ACI). We acknowledge Matthew Dolack for checking data on github. This work was supported in part through instrumentation funded by a National Science Foundation Grant OCI0821527, a Burroughs-Wellcome Fund 2013 Collaborative Research Travel Grant, Pennsylvania Department of Health using Tobacco Cure Funds, and by the National Institutes of Health Grants R01DE022988 and P01HD078233. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Source code of the reaction–diffusion–strain model and an example case are available at https://github.com/PSUCompBio/skull-growth-modeling .
Funding Information:
Computations for this research were performed on the Pennsylvania State University?s Institute for CyberScience Advanced CyberInfrastructure (ICS-ACI). We acknowledge Matthew Dolack for checking data on github. This work was supported in part through instrumentation funded by a National Science Foundation Grant OCI0821527, a Burroughs-Wellcome Fund 2013 Collaborative Research Travel Grant, Pennsylvania Department of Health using Tobacco Cure Funds, and by the National Institutes of Health Grants R01DE022988 and P01HD078233. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Source code of the reaction?diffusion?strain model and an example case are available at https://github.com/PSUCompBio/skull-growth-modeling.
Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - How cells utilize instructions provided by genes and integrate mechanical forces generated by tissue growth to produce morphology is a fundamental question of biology. Dermal bones of the vertebrate cranial vault are formed through the direct differentiation of mesenchymal cells on the neural surface into osteoblasts through intramembranous ossification. Here we join a self-organizing Turing mechanism, computational biomechanics, and experimental data to produce a 3D representative model of the growing cerebral surface, cranial vault bones, and sutures. We show how changes in single parameters regulating signaling during osteoblast differentiation and bone formation may explain cranial vault shape variation in craniofacial disorders. A key result is that toggling a parameter in our model results in closure of a cranial vault suture, an event that occurred during evolution of the cranial vault and that occurs in craniofacial disorders. Our approach provides an initial and important step toward integrating biomechanics into the genotype phenotype map to explain the production of variation in head morphology by developmental mechanisms.
AB - How cells utilize instructions provided by genes and integrate mechanical forces generated by tissue growth to produce morphology is a fundamental question of biology. Dermal bones of the vertebrate cranial vault are formed through the direct differentiation of mesenchymal cells on the neural surface into osteoblasts through intramembranous ossification. Here we join a self-organizing Turing mechanism, computational biomechanics, and experimental data to produce a 3D representative model of the growing cerebral surface, cranial vault bones, and sutures. We show how changes in single parameters regulating signaling during osteoblast differentiation and bone formation may explain cranial vault shape variation in craniofacial disorders. A key result is that toggling a parameter in our model results in closure of a cranial vault suture, an event that occurred during evolution of the cranial vault and that occurs in craniofacial disorders. Our approach provides an initial and important step toward integrating biomechanics into the genotype phenotype map to explain the production of variation in head morphology by developmental mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=85064660863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064660863&partnerID=8YFLogxK
U2 - 10.1007/s10237-019-01139-z
DO - 10.1007/s10237-019-01139-z
M3 - Article
C2 - 31006064
AN - SCOPUS:85064660863
VL - 18
SP - 1197
EP - 1211
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
SN - 1617-7959
IS - 4
ER -