Abstract
How cells utilize instructions provided by genes and integrate mechanical forces generated by tissue growth to produce morphology is a fundamental question of biology. Dermal bones of the vertebrate cranial vault are formed through the direct differentiation of mesenchymal cells on the neural surface into osteoblasts through intramembranous ossification. Here we join a self-organizing Turing mechanism, computational biomechanics, and experimental data to produce a 3D representative model of the growing cerebral surface, cranial vault bones, and sutures. We show how changes in single parameters regulating signaling during osteoblast differentiation and bone formation may explain cranial vault shape variation in craniofacial disorders. A key result is that toggling a parameter in our model results in closure of a cranial vault suture, an event that occurred during evolution of the cranial vault and that occurs in craniofacial disorders. Our approach provides an initial and important step toward integrating biomechanics into the genotype phenotype map to explain the production of variation in head morphology by developmental mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1197-1211 |
| Number of pages | 15 |
| Journal | Biomechanics and Modeling in Mechanobiology |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 15 2019 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Modeling and Simulation
- Mechanical Engineering
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A coupled reaction–diffusion–strain model predicts cranial vault formation in development and disease. / Lee, Chanyoung; Richtsmeier, Joan Therese; Kraft, Reuben H.
In: Biomechanics and Modeling in Mechanobiology, Vol. 18, No. 4, 15.08.2019, p. 1197-1211.Research output: Contribution to journal › Article
TY - JOUR
T1 - A coupled reaction–diffusion–strain model predicts cranial vault formation in development and disease
AU - Lee, Chanyoung
AU - Richtsmeier, Joan Therese
AU - Kraft, Reuben H.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - How cells utilize instructions provided by genes and integrate mechanical forces generated by tissue growth to produce morphology is a fundamental question of biology. Dermal bones of the vertebrate cranial vault are formed through the direct differentiation of mesenchymal cells on the neural surface into osteoblasts through intramembranous ossification. Here we join a self-organizing Turing mechanism, computational biomechanics, and experimental data to produce a 3D representative model of the growing cerebral surface, cranial vault bones, and sutures. We show how changes in single parameters regulating signaling during osteoblast differentiation and bone formation may explain cranial vault shape variation in craniofacial disorders. A key result is that toggling a parameter in our model results in closure of a cranial vault suture, an event that occurred during evolution of the cranial vault and that occurs in craniofacial disorders. Our approach provides an initial and important step toward integrating biomechanics into the genotype phenotype map to explain the production of variation in head morphology by developmental mechanisms.
AB - How cells utilize instructions provided by genes and integrate mechanical forces generated by tissue growth to produce morphology is a fundamental question of biology. Dermal bones of the vertebrate cranial vault are formed through the direct differentiation of mesenchymal cells on the neural surface into osteoblasts through intramembranous ossification. Here we join a self-organizing Turing mechanism, computational biomechanics, and experimental data to produce a 3D representative model of the growing cerebral surface, cranial vault bones, and sutures. We show how changes in single parameters regulating signaling during osteoblast differentiation and bone formation may explain cranial vault shape variation in craniofacial disorders. A key result is that toggling a parameter in our model results in closure of a cranial vault suture, an event that occurred during evolution of the cranial vault and that occurs in craniofacial disorders. Our approach provides an initial and important step toward integrating biomechanics into the genotype phenotype map to explain the production of variation in head morphology by developmental mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=85064660863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064660863&partnerID=8YFLogxK
U2 - 10.1007/s10237-019-01139-z
DO - 10.1007/s10237-019-01139-z
M3 - Article
C2 - 31006064
AN - SCOPUS:85064660863
VL - 18
SP - 1197
EP - 1211
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
SN - 1617-7959
IS - 4
ER -