A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications

Shuo Tang, Kai Chi, Hui Xu, Qiang Yong, Jian Yang, Jeffrey M. Catchmark

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young's modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.

Original languageEnglish (US)
Article number117123
JournalCarbohydrate Polymers
Volume252
DOIs
StatePublished - Jan 15 2021

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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