A critical review on the potential impacts of neonicotinoid insecticide use: Current knowledge of environmental fate, toxicity, and implications for human health

Darrin A. Thompson, Hans Joachim Lehmler, Dana W. Kolpin, Michelle L. Hladik, John D. Vargo, Keith E. Schilling, Gregory H. Lefevre, Tonya L. Peeples, Matthew C. Poch, Lauren E. Laduca, David M. Cwiertny, R. William Field

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Neonicotinoids are found to be ubiquitous in the environment, drinking water, and food, with low-level exposure commonly documented below acceptable daily intake standards. Available toxicological data from animal studies indicate possible genotoxicity, cytotoxicity, impaired immune function, and reduced growth and reproductive success at low concentrations, while limited data from ecological or cross-sectional epidemiological studies have identified acute and chronic health effects ranging from acute respiratory, cardiovascular, and neurological symptoms to oxidative genetic damage and birth defects. Due to the heavy use of neonicotinoids and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understand their risks to humans.

Original languageEnglish (US)
Pages (from-to)1315-1346
Number of pages32
JournalEnvironmental Science: Processes and Impacts
Volume22
Issue number6
DOIs
StatePublished - Jun 2020

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Management, Monitoring, Policy and Law

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    Thompson, D. A., Lehmler, H. J., Kolpin, D. W., Hladik, M. L., Vargo, J. D., Schilling, K. E., Lefevre, G. H., Peeples, T. L., Poch, M. C., Laduca, L. E., Cwiertny, D. M., & Field, R. W. (2020). A critical review on the potential impacts of neonicotinoid insecticide use: Current knowledge of environmental fate, toxicity, and implications for human health. Environmental Science: Processes and Impacts, 22(6), 1315-1346. https://doi.org/10.1039/c9em00586b