(formula presented) The anticancer drug etoposide, 1, Is prepared in 79% overall yield from readily available 4′-demethyl-4-epipodophyllotoxin, 3, and 4,6-O-ethylidene-2,3-O-dibenzyl-D-glucose, 4, via a crystallization-induced stereoselective glycosidation reaction followed by catalytic hydrogenation.
|Original language||English (US)|
|Number of pages||3|
|Publication status||Published - Oct 19 2000|
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry