A decade of clinical trial developments in postmyocardial infarction, congestive heart failure, and sustained ventricular tachyarrhythmia patients: From CAST to AVID and beyond

Gerald Naccarelli, Deborah Wolbrette, Joseph T. Dell'Orfano, Hemantkumar M. Patel, Jerry C. Luck

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Multiple trials using antiarrhythmic drugs, pharmacologic therapy, and implantable cardioverter defibrillators have been performed in an attempt to improve survival in patients: (1) postmyocardial infarction; (2) with congestive heart failure, with and without nonsustained ventricular tachycardia; and (3) with sustained ventricular tachycardia and those who have survived an out-of-hospital cardiac arrest. This article reviews some of the key findings and limitations of completed and ongoing trials. We also make recommendations for the current treatment of such patients based on the results of these trials.

Original languageEnglish (US)
Pages (from-to)864-891
Number of pages28
JournalJournal of cardiovascular electrophysiology
Volume9
Issue number8
StatePublished - Sep 2 1998

Fingerprint

Ventricular Tachycardia
Tachycardia
Infarction
Heart Failure
Clinical Trials
Out-of-Hospital Cardiac Arrest
Implantable Defibrillators
Anti-Arrhythmia Agents
Drug Therapy
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

@article{8e48301ef28945869d5d46aa8ffcf3f0,
title = "A decade of clinical trial developments in postmyocardial infarction, congestive heart failure, and sustained ventricular tachyarrhythmia patients: From CAST to AVID and beyond",
abstract = "Multiple trials using antiarrhythmic drugs, pharmacologic therapy, and implantable cardioverter defibrillators have been performed in an attempt to improve survival in patients: (1) postmyocardial infarction; (2) with congestive heart failure, with and without nonsustained ventricular tachycardia; and (3) with sustained ventricular tachycardia and those who have survived an out-of-hospital cardiac arrest. This article reviews some of the key findings and limitations of completed and ongoing trials. We also make recommendations for the current treatment of such patients based on the results of these trials.",
author = "Gerald Naccarelli and Deborah Wolbrette and Dell'Orfano, {Joseph T.} and Patel, {Hemantkumar M.} and Luck, {Jerry C.}",
year = "1998",
month = "9",
day = "2",
language = "English (US)",
volume = "9",
pages = "864--891",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - A decade of clinical trial developments in postmyocardial infarction, congestive heart failure, and sustained ventricular tachyarrhythmia patients

T2 - From CAST to AVID and beyond

AU - Naccarelli, Gerald

AU - Wolbrette, Deborah

AU - Dell'Orfano, Joseph T.

AU - Patel, Hemantkumar M.

AU - Luck, Jerry C.

PY - 1998/9/2

Y1 - 1998/9/2

N2 - Multiple trials using antiarrhythmic drugs, pharmacologic therapy, and implantable cardioverter defibrillators have been performed in an attempt to improve survival in patients: (1) postmyocardial infarction; (2) with congestive heart failure, with and without nonsustained ventricular tachycardia; and (3) with sustained ventricular tachycardia and those who have survived an out-of-hospital cardiac arrest. This article reviews some of the key findings and limitations of completed and ongoing trials. We also make recommendations for the current treatment of such patients based on the results of these trials.

AB - Multiple trials using antiarrhythmic drugs, pharmacologic therapy, and implantable cardioverter defibrillators have been performed in an attempt to improve survival in patients: (1) postmyocardial infarction; (2) with congestive heart failure, with and without nonsustained ventricular tachycardia; and (3) with sustained ventricular tachycardia and those who have survived an out-of-hospital cardiac arrest. This article reviews some of the key findings and limitations of completed and ongoing trials. We also make recommendations for the current treatment of such patients based on the results of these trials.

UR - http://www.scopus.com/inward/record.url?scp=0031845983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031845983&partnerID=8YFLogxK

M3 - Review article

C2 - 9727666

AN - SCOPUS:0031845983

VL - 9

SP - 864

EP - 891

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

IS - 8

ER -