A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients

Gordon L. Jensen, Robert H. Miller, David G. Talabiska, Judith Fish, Lisa Gianferante

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Arterial and venous plasma amino acids were determined in 28 intensive care patients randomly assigned to receive 10 d of isoenergetic, isonitrogenous feedings that differed sixfold in glutamine content. Subjects were generally well-matched for age, injury severity, and disease diagnoses. Nasojejunal feedings were started within 48 h of admission. Data were analyzed from those 19 subjects still receiving ≤ 50 mL feeding/h on day 5. Both groups had comparable gastric residuals, stool frequency, and delivered nitrogen and energy. At study initiation, all subjects had relative hypoaminoacidemia, with day 1 venous glutamine concentrations down 26% compared with reference values. Plasma glutamine rose to comparable concentrations with feeding of either diet. There were, however, significant (P < 0.05) increases in arterial or venous plasma total, indispensable, and branched-chain amino acids of 125-144% by day 5 only in patients fed the standard control diet. The phenylalanine-tyrosine ratio was elevated on day 1 in both groups (1.3-1.4) but decreased significantly only in the glutamine- supplemented group (1.1 compared with 1.4) by day 5. Glutamine supplementation blunted the hyperaminoacidemia and elevated aromatic amino acid response to injury.

Original languageEnglish (US)
Pages (from-to)615-621
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume64
Issue number4
DOIs
StatePublished - Oct 1996

Fingerprint

Glutamine
Critical Illness
Prospective Studies
Peptides
Diet
Branched Chain Amino Acids
Aromatic Amino Acids
Wounds and Injuries
Critical Care
Phenylalanine
Tyrosine
Stomach
Reference Values
Nitrogen
Amino Acids

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Jensen, Gordon L. ; Miller, Robert H. ; Talabiska, David G. ; Fish, Judith ; Gianferante, Lisa. / A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients. In: American Journal of Clinical Nutrition. 1996 ; Vol. 64, No. 4. pp. 615-621.
@article{2ae9f353965d4c57b4f390d952a0b2ff,
title = "A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients",
abstract = "Arterial and venous plasma amino acids were determined in 28 intensive care patients randomly assigned to receive 10 d of isoenergetic, isonitrogenous feedings that differed sixfold in glutamine content. Subjects were generally well-matched for age, injury severity, and disease diagnoses. Nasojejunal feedings were started within 48 h of admission. Data were analyzed from those 19 subjects still receiving ≤ 50 mL feeding/h on day 5. Both groups had comparable gastric residuals, stool frequency, and delivered nitrogen and energy. At study initiation, all subjects had relative hypoaminoacidemia, with day 1 venous glutamine concentrations down 26{\%} compared with reference values. Plasma glutamine rose to comparable concentrations with feeding of either diet. There were, however, significant (P < 0.05) increases in arterial or venous plasma total, indispensable, and branched-chain amino acids of 125-144{\%} by day 5 only in patients fed the standard control diet. The phenylalanine-tyrosine ratio was elevated on day 1 in both groups (1.3-1.4) but decreased significantly only in the glutamine- supplemented group (1.1 compared with 1.4) by day 5. Glutamine supplementation blunted the hyperaminoacidemia and elevated aromatic amino acid response to injury.",
author = "Jensen, {Gordon L.} and Miller, {Robert H.} and Talabiska, {David G.} and Judith Fish and Lisa Gianferante",
year = "1996",
month = "10",
doi = "10.1093/ajcn/64.4.615",
language = "English (US)",
volume = "64",
pages = "615--621",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "4",

}

A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients. / Jensen, Gordon L.; Miller, Robert H.; Talabiska, David G.; Fish, Judith; Gianferante, Lisa.

In: American Journal of Clinical Nutrition, Vol. 64, No. 4, 10.1996, p. 615-621.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients

AU - Jensen, Gordon L.

AU - Miller, Robert H.

AU - Talabiska, David G.

AU - Fish, Judith

AU - Gianferante, Lisa

PY - 1996/10

Y1 - 1996/10

N2 - Arterial and venous plasma amino acids were determined in 28 intensive care patients randomly assigned to receive 10 d of isoenergetic, isonitrogenous feedings that differed sixfold in glutamine content. Subjects were generally well-matched for age, injury severity, and disease diagnoses. Nasojejunal feedings were started within 48 h of admission. Data were analyzed from those 19 subjects still receiving ≤ 50 mL feeding/h on day 5. Both groups had comparable gastric residuals, stool frequency, and delivered nitrogen and energy. At study initiation, all subjects had relative hypoaminoacidemia, with day 1 venous glutamine concentrations down 26% compared with reference values. Plasma glutamine rose to comparable concentrations with feeding of either diet. There were, however, significant (P < 0.05) increases in arterial or venous plasma total, indispensable, and branched-chain amino acids of 125-144% by day 5 only in patients fed the standard control diet. The phenylalanine-tyrosine ratio was elevated on day 1 in both groups (1.3-1.4) but decreased significantly only in the glutamine- supplemented group (1.1 compared with 1.4) by day 5. Glutamine supplementation blunted the hyperaminoacidemia and elevated aromatic amino acid response to injury.

AB - Arterial and venous plasma amino acids were determined in 28 intensive care patients randomly assigned to receive 10 d of isoenergetic, isonitrogenous feedings that differed sixfold in glutamine content. Subjects were generally well-matched for age, injury severity, and disease diagnoses. Nasojejunal feedings were started within 48 h of admission. Data were analyzed from those 19 subjects still receiving ≤ 50 mL feeding/h on day 5. Both groups had comparable gastric residuals, stool frequency, and delivered nitrogen and energy. At study initiation, all subjects had relative hypoaminoacidemia, with day 1 venous glutamine concentrations down 26% compared with reference values. Plasma glutamine rose to comparable concentrations with feeding of either diet. There were, however, significant (P < 0.05) increases in arterial or venous plasma total, indispensable, and branched-chain amino acids of 125-144% by day 5 only in patients fed the standard control diet. The phenylalanine-tyrosine ratio was elevated on day 1 in both groups (1.3-1.4) but decreased significantly only in the glutamine- supplemented group (1.1 compared with 1.4) by day 5. Glutamine supplementation blunted the hyperaminoacidemia and elevated aromatic amino acid response to injury.

UR - http://www.scopus.com/inward/record.url?scp=0029786429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029786429&partnerID=8YFLogxK

U2 - 10.1093/ajcn/64.4.615

DO - 10.1093/ajcn/64.4.615

M3 - Article

C2 - 8839508

AN - SCOPUS:0029786429

VL - 64

SP - 615

EP - 621

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -