A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults

Richard Berger, Alicia Barba, Alan Fleischer, James J. Leyden, Anne Lucky, David Pariser, Elyse Rafal, Diane Thiboutot, David Wilson, Rachel Grossman, Marge Nighland

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Abstract

This double-blinded, randomized, vehicle-controlled, multicenter, parallel-group, 12-week, phase 4 study was conducted in adults with mild to moderate acne vulgaris. Of 178 subjects randomized to be treated, 88 subjects (49%) were treated with tretinoin gel microsphere 0.04% and 90 subjects (51%) were treated with vehicle. Inflammatory lesion counts were statistically significantly reduced at 2 weeks in tretinoin-treated subjects (P = .0110), and reductions in total lesion counts also were noted. The reduction in total lesion counts reached statistical significance at week 4 (P = .0305); at week 12, mean total, inflammatory, and noninflammatory lesion counts were statistically significantly lower in the tretinoin treatment group versus vehicle group (P<.05), and mean percentage reductions in lesion counts were significantly greater in the subjects with noninflammatory lesions treated with tretinoin compared with vehicle (P<.05). Mean percentage reductions in total, inflammatory, and noninflammatory lesion counts were 35.5%, 38.2%, and 33.6%, respectively, at week 12 for the tretinoin treatment group compared with 20.9%, 19.2%, and 20.4%, respectively, for the vehicle group (all P<.05). All adverse events were of mild or moderate intensity with the exception of severe skin irritation in one tretinoin-treated subject. At week 12, there were no statistically significant differences between treatment groups for any measured tolerability parameter.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalCutis
Volume80
Issue number2
StatePublished - Aug 1 2007

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All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Berger, R., Barba, A., Fleischer, A., Leyden, J. J., Lucky, A., Pariser, D., Rafal, E., Thiboutot, D., Wilson, D., Grossman, R., & Nighland, M. (2007). A double-blinded, randomized, vehicle-controlled, multicenter, parallel-group study to assess the safety and efficacy of tretinoin gel microsphere 0.04% in the treatment of acne vulgaris in adults. Cutis, 80(2), 152-157.