A dynamical systems model of intrauterine fetal growth

Mohammad T. Freigoun, Daniel E. Rivera, Penghong Guo, Emily Hohman, Alison Diane Gernand, Danielle Symons Downs, Jennifer Savage Williams

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The underlying mechanisms for how maternal perinatal obesity and intrauterine environment influence foetal development are not well understood and thus require further understanding. In this paper, energy balance concepts are used to develop a comprehensive dynamical systems model for foetal growth that illustrates how maternal factors (energy intake and physical activity) influence foetal weight and related components (fat mass, fat-free mass, and placental volume) over time. The model is estimated from intensive measurements of foetal weight and placental volume obtained as part of Healthy Mom Zone (HMZ), a novel intervention for managing gestational weight gain in obese/overweight women. The overall result of the modelling procedure is a parsimonious system of equations that reliably predicts foetal weight gain and birth weight based on a sensible number of assessments. This model can inform clinical care recommendations as well as how adaptive interventions, such as HMZ, can influence foetal growth and birth outcomes.

Original languageEnglish (US)
Pages (from-to)641-667
Number of pages27
JournalMathematical and Computer Modelling of Dynamical Systems
Volume24
Issue number6
DOIs
StatePublished - Nov 2 2018

Fingerprint

Dynamical systems
Dynamical system
Oils and fats
Energy balance
Obesity
Model
Energy Balance
System of equations
Recommendations
Predict
Energy
Modeling
Influence
Energy Intake

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Software
  • Modeling and Simulation
  • Computer Science Applications
  • Applied Mathematics

Cite this

@article{4a75ca8f25834386b0297d4c4d7e2f8e,
title = "A dynamical systems model of intrauterine fetal growth",
abstract = "The underlying mechanisms for how maternal perinatal obesity and intrauterine environment influence foetal development are not well understood and thus require further understanding. In this paper, energy balance concepts are used to develop a comprehensive dynamical systems model for foetal growth that illustrates how maternal factors (energy intake and physical activity) influence foetal weight and related components (fat mass, fat-free mass, and placental volume) over time. The model is estimated from intensive measurements of foetal weight and placental volume obtained as part of Healthy Mom Zone (HMZ), a novel intervention for managing gestational weight gain in obese/overweight women. The overall result of the modelling procedure is a parsimonious system of equations that reliably predicts foetal weight gain and birth weight based on a sensible number of assessments. This model can inform clinical care recommendations as well as how adaptive interventions, such as HMZ, can influence foetal growth and birth outcomes.",
author = "Freigoun, {Mohammad T.} and Rivera, {Daniel E.} and Penghong Guo and Emily Hohman and Gernand, {Alison Diane} and Downs, {Danielle Symons} and Williams, {Jennifer Savage}",
year = "2018",
month = "11",
day = "2",
doi = "10.1080/13873954.2018.1524387",
language = "English (US)",
volume = "24",
pages = "641--667",
journal = "Mathematical and Computer Modelling of Dynamical Systems",
issn = "1387-3954",
publisher = "Taylor and Francis Ltd.",
number = "6",

}

A dynamical systems model of intrauterine fetal growth. / Freigoun, Mohammad T.; Rivera, Daniel E.; Guo, Penghong; Hohman, Emily; Gernand, Alison Diane; Downs, Danielle Symons; Williams, Jennifer Savage.

In: Mathematical and Computer Modelling of Dynamical Systems, Vol. 24, No. 6, 02.11.2018, p. 641-667.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A dynamical systems model of intrauterine fetal growth

AU - Freigoun, Mohammad T.

AU - Rivera, Daniel E.

AU - Guo, Penghong

AU - Hohman, Emily

AU - Gernand, Alison Diane

AU - Downs, Danielle Symons

AU - Williams, Jennifer Savage

PY - 2018/11/2

Y1 - 2018/11/2

N2 - The underlying mechanisms for how maternal perinatal obesity and intrauterine environment influence foetal development are not well understood and thus require further understanding. In this paper, energy balance concepts are used to develop a comprehensive dynamical systems model for foetal growth that illustrates how maternal factors (energy intake and physical activity) influence foetal weight and related components (fat mass, fat-free mass, and placental volume) over time. The model is estimated from intensive measurements of foetal weight and placental volume obtained as part of Healthy Mom Zone (HMZ), a novel intervention for managing gestational weight gain in obese/overweight women. The overall result of the modelling procedure is a parsimonious system of equations that reliably predicts foetal weight gain and birth weight based on a sensible number of assessments. This model can inform clinical care recommendations as well as how adaptive interventions, such as HMZ, can influence foetal growth and birth outcomes.

AB - The underlying mechanisms for how maternal perinatal obesity and intrauterine environment influence foetal development are not well understood and thus require further understanding. In this paper, energy balance concepts are used to develop a comprehensive dynamical systems model for foetal growth that illustrates how maternal factors (energy intake and physical activity) influence foetal weight and related components (fat mass, fat-free mass, and placental volume) over time. The model is estimated from intensive measurements of foetal weight and placental volume obtained as part of Healthy Mom Zone (HMZ), a novel intervention for managing gestational weight gain in obese/overweight women. The overall result of the modelling procedure is a parsimonious system of equations that reliably predicts foetal weight gain and birth weight based on a sensible number of assessments. This model can inform clinical care recommendations as well as how adaptive interventions, such as HMZ, can influence foetal growth and birth outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85054528772&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054528772&partnerID=8YFLogxK

U2 - 10.1080/13873954.2018.1524387

DO - 10.1080/13873954.2018.1524387

M3 - Article

C2 - 30498392

AN - SCOPUS:85054528772

VL - 24

SP - 641

EP - 667

JO - Mathematical and Computer Modelling of Dynamical Systems

JF - Mathematical and Computer Modelling of Dynamical Systems

SN - 1387-3954

IS - 6

ER -