A fast degradable citrate-based bone scaffold promotes spinal fusion

Jiajun Tang, Jinshan Guo, Zhen Li, Cheng Yang, Denghui Xie, Jian Chen, Shengfa Li, Shaolin Li, Gloria B. Kim, Xiaochun Bai, Zhongmin Zhang, Jian Yang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

It is well known that high rates of fusion failure and pseudoarthrosis development (5-35%) are concomitant in spinal fusion surgery, which was ascribed to the shortage of suitable materials for bone regeneration. Citrate was recently recognized to play an indispensable role in enhancing osteoconductivity and osteoinductivity, and promoting bone formation. To address the material challenges in spinal fusion surgery, we have synthesized mechanically robust and fast degrading citrate-based polymers by incorporating N-methyldiethanolamine (MDEA) into clickable poly(1,8-octanediol citrates) (POC-click), referred to as POC-M-click. The obtained POC-M-click were fabricated into POC-M-click-HA matchstick scaffolds by forming composites with hydroxyapatite (HA) for interbody spinal fusion in a rabbit model. Spinal fusion was analyzed by radiography, manual palpation, biomechanical testing, and histological evaluation. At 4 and 8 weeks post surgery, POC-M-click-HA scaffolds showed optimal degradation rates that facilitated faster new bone formation and higher spinal fusion rates (11.2 ± 3.7, 80 ± 4.5 at week 4 and 8, respectively) than the poly(l-lactic acid)-HA (PLLA-HA) control group (9.3 ± 2.4 and 71.1 ± 4.4) (p < 0.05). The POC-M-click-HA scaffold-fused vertebrates possessed a maximum load and stiffness of 880.8 ± 14.5 N and 843.2 ± 22.4 N mm-1, respectively, which were also much higher than those of the PLLA-HA group (maximum: 712.0 ± 37.5 N, stiffness: 622.5 ± 28.4 N mm-1, p < 0.05). Overall, the results suggest that POC-M-click-HA scaffolds could potentially serve as promising bone grafts for spinal fusion applications.

Original languageEnglish (US)
Pages (from-to)5569-5576
Number of pages8
JournalJournal of Materials Chemistry B
Volume3
Issue number27
DOIs
StatePublished - Jul 21 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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