A focus on reward prediction and the lateral habenula

Functional alterations and the behavioral outcomes induced by drugs of abuse

Nicholas Graziane, Peter A. Neumann, Yan Dong

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Abstract

The lateral habenula (LHb) regulates reward learning and controls the updating of reward-related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit mechanisms mediating reward learning, forming non-adaptable, compulsive behaviors geared toward obtaining illicit substances. Here, we discuss current findings demonstrating how drugs of abuse alter intrinsic and synaptic LHb neuronal function. Additionally, we discuss evidence for how drug-induced LHb alterations may affect the ability to predict reward, potentially facilitating an addiction-like state. Altogether, we combine ex vivo and in vivo results for an overview of how drugs of abuse alter LHb function and how these functional alterations affect the ability to learn and update behavioral responses to hedonic external stimuli.

Original languageEnglish (US)
Article number12
JournalFrontiers in Synaptic Neuroscience
Volume10
Issue numberMAY
DOIs
StatePublished - May 29 2018

Fingerprint

Habenula
Street Drugs
Reward
Aptitude
Learning
Compulsive Behavior
Pleasure
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

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A focus on reward prediction and the lateral habenula : Functional alterations and the behavioral outcomes induced by drugs of abuse. / Graziane, Nicholas; Neumann, Peter A.; Dong, Yan.

In: Frontiers in Synaptic Neuroscience, Vol. 10, No. MAY, 12, 29.05.2018.

Research output: Contribution to journalShort survey

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AB - The lateral habenula (LHb) regulates reward learning and controls the updating of reward-related information. Drugs of abuse have the capacity to hijack the cellular and neurocircuit mechanisms mediating reward learning, forming non-adaptable, compulsive behaviors geared toward obtaining illicit substances. Here, we discuss current findings demonstrating how drugs of abuse alter intrinsic and synaptic LHb neuronal function. Additionally, we discuss evidence for how drug-induced LHb alterations may affect the ability to predict reward, potentially facilitating an addiction-like state. Altogether, we combine ex vivo and in vivo results for an overview of how drugs of abuse alter LHb function and how these functional alterations affect the ability to learn and update behavioral responses to hedonic external stimuli.

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