A folding pathway-dependent score to recognize membrane proteins

Hamid Hadi-Alijanvand, Maryam Rouhani, Elizabeth A. Proctor, Nikolay V. Dokholyan, Ali A. Moosavi-Movahedi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP3mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP3mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.

Original languageEnglish (US)
Article numbere16778
JournalPloS one
Volume6
Issue number3
DOIs
StatePublished - Mar 10 2011

Fingerprint

membrane proteins
Membrane Proteins
Membranes
proteins
Proteins
principal component analysis
Principal Component Analysis
Principal component analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Hadi-Alijanvand, Hamid ; Rouhani, Maryam ; Proctor, Elizabeth A. ; Dokholyan, Nikolay V. ; Moosavi-Movahedi, Ali A. / A folding pathway-dependent score to recognize membrane proteins. In: PloS one. 2011 ; Vol. 6, No. 3.
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A folding pathway-dependent score to recognize membrane proteins. / Hadi-Alijanvand, Hamid; Rouhani, Maryam; Proctor, Elizabeth A.; Dokholyan, Nikolay V.; Moosavi-Movahedi, Ali A.

In: PloS one, Vol. 6, No. 3, e16778, 10.03.2011.

Research output: Contribution to journalArticle

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