A fully integrated microdevice for clinical analysis

Jerome P. Ferrance, Joan Bienvenue, Lindsay Legendre, Chris Easley, James Karlinsey, Michael G. Roper, James P. Landers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Micro-total analysis systems provide sample-in/answer-out processing, incorporating both sample preparation and analysis steps. This work focused on integration of DNA extraction and PCR amplification steps with an electrophoretic separation and fluorescence detection. Fully integrated chip-based analysis was demonstrated with an anthrax sporespiked nasal swab as the sample, and detection of the anthrax-specific amplified product as the diagnostic read-out. Additional work is aimed at the development of other sample processing steps and pressure-based injections on these microdevices.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages794-795
Number of pages2
ISBN (Print)0974361119, 9780974361116
Publication statusPublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Ferrance, J. P., Bienvenue, J., Legendre, L., Easley, C., Karlinsey, J., Roper, M. G., & Landers, J. P. (2005). A fully integrated microdevice for clinical analysis. In Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 794-795). (Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences; Vol. 1). Transducer Research Foundation.