A functional magnetic resonance imaging study of head movements in cervical dystonia

Cecília N. Prudente, Randall Stilla, Shivangi Singh, Cathrin Buetefisch, Marian Evatt, Stewart A. Factor, Alan Freeman, Xiaoping Philip Hu, Ellen J. Hess, K. Sathian, H. A. Jinnah

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

Original languageEnglish (US)
Article number201
JournalFrontiers in Neurology
Volume7
Issue numberNOV
DOIs
StatePublished - Nov 15 2016

Fingerprint

Torticollis
Head Movements
Magnetic Resonance Imaging
Head
Dyskinesias
Cerebellum
Brain
Neck Muscles
Electromyography
Muscle Contraction
Nervous System Diseases
Wrist
Posture
Cerebral Cortex
Hand
Direction compound

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Prudente, C. N., Stilla, R., Singh, S., Buetefisch, C., Evatt, M., Factor, S. A., ... Jinnah, H. A. (2016). A functional magnetic resonance imaging study of head movements in cervical dystonia. Frontiers in Neurology, 7(NOV), [201]. https://doi.org/10.3389/fneur.2016.00201
Prudente, Cecília N. ; Stilla, Randall ; Singh, Shivangi ; Buetefisch, Cathrin ; Evatt, Marian ; Factor, Stewart A. ; Freeman, Alan ; Hu, Xiaoping Philip ; Hess, Ellen J. ; Sathian, K. ; Jinnah, H. A. / A functional magnetic resonance imaging study of head movements in cervical dystonia. In: Frontiers in Neurology. 2016 ; Vol. 7, No. NOV.
@article{89ceaa1eeaf64850882a7cd20a846f74,
title = "A functional magnetic resonance imaging study of head movements in cervical dystonia",
abstract = "Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.",
author = "Prudente, {Cec{\'i}lia N.} and Randall Stilla and Shivangi Singh and Cathrin Buetefisch and Marian Evatt and Factor, {Stewart A.} and Alan Freeman and Hu, {Xiaoping Philip} and Hess, {Ellen J.} and K. Sathian and Jinnah, {H. A.}",
year = "2016",
month = "11",
day = "15",
doi = "10.3389/fneur.2016.00201",
language = "English (US)",
volume = "7",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "NOV",

}

Prudente, CN, Stilla, R, Singh, S, Buetefisch, C, Evatt, M, Factor, SA, Freeman, A, Hu, XP, Hess, EJ, Sathian, K & Jinnah, HA 2016, 'A functional magnetic resonance imaging study of head movements in cervical dystonia', Frontiers in Neurology, vol. 7, no. NOV, 201. https://doi.org/10.3389/fneur.2016.00201

A functional magnetic resonance imaging study of head movements in cervical dystonia. / Prudente, Cecília N.; Stilla, Randall; Singh, Shivangi; Buetefisch, Cathrin; Evatt, Marian; Factor, Stewart A.; Freeman, Alan; Hu, Xiaoping Philip; Hess, Ellen J.; Sathian, K.; Jinnah, H. A.

In: Frontiers in Neurology, Vol. 7, No. NOV, 201, 15.11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A functional magnetic resonance imaging study of head movements in cervical dystonia

AU - Prudente, Cecília N.

AU - Stilla, Randall

AU - Singh, Shivangi

AU - Buetefisch, Cathrin

AU - Evatt, Marian

AU - Factor, Stewart A.

AU - Freeman, Alan

AU - Hu, Xiaoping Philip

AU - Hess, Ellen J.

AU - Sathian, K.

AU - Jinnah, H. A.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

AB - Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

UR - http://www.scopus.com/inward/record.url?scp=85006093147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006093147&partnerID=8YFLogxK

U2 - 10.3389/fneur.2016.00201

DO - 10.3389/fneur.2016.00201

M3 - Article

AN - SCOPUS:85006093147

VL - 7

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - NOV

M1 - 201

ER -

Prudente CN, Stilla R, Singh S, Buetefisch C, Evatt M, Factor SA et al. A functional magnetic resonance imaging study of head movements in cervical dystonia. Frontiers in Neurology. 2016 Nov 15;7(NOV). 201. https://doi.org/10.3389/fneur.2016.00201