A functional study of platelets in menstrual fluid

MARGARET C.P. REES, LAURENCE M. DEMERS, ANNE B.M. ANDERSON, A. C. TURNBULL

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Platelets were isolated from menstrual and peripheral venous blood samples taken from nine women during the first 2 days of menstruation. The washed platelets were tested for their ability to aggregate in response to arachidonic acid, ADP, and collagen, and to metabolize arachidonic acid. Menstrual platelets differed from venous platelets in (1) failing to aggregate when challenged with aggregatory stimuli and (2) producing no appreciable cyclo‐oxygenase products from arachidonic acid as reflected in thromboxane B2 release. However, incubation of peripheral venous platelets with menstrual serum obtained from the same patients induced aggregation. The responses of menstrual and peripheral venous platelets were the same irrespective of the patients’ total menstrual blood loss. Uterine venous platelets collected during menstruation from two patients at hysterectomy aggregated normally and produced thromboxane B2.

Original languageEnglish (US)
Pages (from-to)667-672
Number of pages6
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Volume91
Issue number7
DOIs
StatePublished - Jul 1984

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Blood Platelets
Thromboxane B2
Menstruation
Arachidonic Acid
Prostaglandin-Endoperoxide Synthases
Hysterectomy
Adenosine Diphosphate
Collagen
Serum

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

REES, MARGARET. C. P., DEMERS, LAURENCE. M., ANDERSON, ANNE. B. M., & TURNBULL, A. C. (1984). A functional study of platelets in menstrual fluid. BJOG: An International Journal of Obstetrics & Gynaecology, 91(7), 667-672. https://doi.org/10.1111/j.1471-0528.1984.tb04828.x
REES, MARGARET C.P. ; DEMERS, LAURENCE M. ; ANDERSON, ANNE B.M. ; TURNBULL, A. C. / A functional study of platelets in menstrual fluid. In: BJOG: An International Journal of Obstetrics & Gynaecology. 1984 ; Vol. 91, No. 7. pp. 667-672.
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REES, MARGARETCP, DEMERS, LAURENCEM, ANDERSON, ANNEBM & TURNBULL, AC 1984, 'A functional study of platelets in menstrual fluid', BJOG: An International Journal of Obstetrics & Gynaecology, vol. 91, no. 7, pp. 667-672. https://doi.org/10.1111/j.1471-0528.1984.tb04828.x

A functional study of platelets in menstrual fluid. / REES, MARGARET C.P.; DEMERS, LAURENCE M.; ANDERSON, ANNE B.M.; TURNBULL, A. C.

In: BJOG: An International Journal of Obstetrics & Gynaecology, Vol. 91, No. 7, 07.1984, p. 667-672.

Research output: Contribution to journalArticle

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