A functional workbench for anopheles gambiae micro array analysis

Marion Adebiyi, Josiah Oghuan, Segun Fatumo, Ezekiel Adebiyi, Jason Rasgon

Research output: Contribution to conferencePaper

Abstract

Insecticide resistance, a character inherited that encompasses alteration in one or more of insect's genes is now a major public health challenge combating world efforts onmalaria control strategies. Anopheles has developed heavyresistance to pyrethroids, the only World Health Organization (WHO) recommended class for Indoor Residual Spray (IRS) and Long-Lasting Insecticide Treated Nets (LLITNs) through P450 pathways. We used the biochemical network of Anopheles gambiae (henceforth Ag) to deduce its resistance mechanism(s) using two expression data (when Ag is treated with pyrethroid and when controlled). The employed computational techniques are accessible by a robust, multi-faceted and friendly automated graphic user interface (GUI) tagged 'workbench' with JavaFX Scenebuilder. In this work, we introduced a computational platform to determine and also elucidate for the first time resistance mechanism to a commonly used class of insecticide, Pyrethroid. Significantly, our work is the firstcomputational work to identify genes associated or involved in the efflux system in Ag and as a resistance mechanism in the Anopheles.

Original languageEnglish (US)
Pages138-143
Number of pages6
DOIs
StatePublished - Jan 1 2013
EventUKSim-AMSS 7th European Modelling Symposium on Computer Modelling and Simulation, EMS 2013 - Manchester, United Kingdom
Duration: Nov 20 2013Nov 22 2013

Other

OtherUKSim-AMSS 7th European Modelling Symposium on Computer Modelling and Simulation, EMS 2013
CountryUnited Kingdom
CityManchester
Period11/20/1311/22/13

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All Science Journal Classification (ASJC) codes

  • Modeling and Simulation

Cite this

Adebiyi, M., Oghuan, J., Fatumo, S., Adebiyi, E., & Rasgon, J. (2013). A functional workbench for anopheles gambiae micro array analysis. 138-143. Paper presented at UKSim-AMSS 7th European Modelling Symposium on Computer Modelling and Simulation, EMS 2013, Manchester, United Kingdom. https://doi.org/10.1109/EMS.2013.24