A functionally gradient variational porosity architecture for hollowed scaffolds fabrication

A. K.M. Khoda, Ibrahim Tarik Ozbolat, Bahattin Koc

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

This paper presents a novel continuous tool-path planning methodology for hollowed scaffold fabrication in tissue engineering. A new functionally gradient porous architecture is proposed with a continuous material deposition planning scheme. A controllable variational pore size and hence the porosity have been achieved with a combination of two geometrically oriented consecutive layers. The desired porosity has been achieved with consecutive layers by geometrically partitioning each layer into sub-regions based on the area and the tissue scaffold design constraints. A continuous, interconnected and optimized tool-path for layers has been generated for a three-dimensional biomaterial deposition/printing process. A zigzag pattern tool-path has been proposed for an accumulated sub-region layer, and a concentric spiral-like optimal tool-path pattern has been generated for the successive layer to ensure continuity along the structure. Three-dimensional layers, formed by the proposed tool-path plan, vary the pore size and the porosity based on the biological and mechanical requirements. Several examples demonstrate the proposed methodology along with illustrative results. Also a comparative study between the proposed design and conventional Cartesian coordinate scaffolds has been performed. The results demonstrate a significant reduction in design error with the proposed method. Moreover, sample examples have been fabricated using a micro-nozzle biomaterial deposition system, and characterized for validation.

Original languageEnglish (US)
Article number034106
JournalBiofabrication
Volume3
Issue number3
DOIs
StatePublished - Sep 1 2011

Fingerprint

Porosity
Scaffolds
Biocompatible Materials
Fabrication
Planning Techniques
Tissue Scaffolds
Printing
Biomaterials
Pore size
Tissue Engineering
Scaffolds (biology)
Motion planning
Tissue engineering
Nozzles
Planning

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Cite this

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A functionally gradient variational porosity architecture for hollowed scaffolds fabrication. / Khoda, A. K.M.; Ozbolat, Ibrahim Tarik; Koc, Bahattin.

In: Biofabrication, Vol. 3, No. 3, 034106, 01.09.2011.

Research output: Contribution to journalArticle

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