A Gene Related to the Proto-Oncogene fps/fes Is Expressed at Diverse Times during the Life Cycle of Drosophila melanogaster

Alisa L. Katzen, Didier Montarras, Jean Jackson, Robert F. Paulson, Thomas Kornberg, J. Michael Bishop

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The proto-oncogene fps/fes encodes a distinctive type of protein-tyrosine kinase. We identified a Drosophila gene (dfps85D) whose product resembles the proteins encoded by vertebrate fps/fes and the closely related gene fer. dfps85D is located at chromosomal position 85D10-13 and is unlikely to correspond to any previously defined genetic locus in Drosophila melanogaster. Expression of the gene is entirely zygotic in origin and occurs throughout the life cycle. But hybridization in situ revealed that the pattern of expression is specialized and evolves in a provocative manner. The most notable feature of expression is the diversity of developmental periods, tissues, and cells in which it occurs. In some tissues, expression is transient; in others, it is continuous. Expression occurs in both mitotic and terminally differentiated tissue and, at various times in development, is prominent in imaginai disks, gut, muscle, testes, ovaries, retina, and other neural tissues. It appears that the use of dfps85D is more diversified than that of other Drosophila protein-tyrosine kinases reported to date and contrasts sharply with the restricted expression of fps itself in vertebrates. The detailed description of expression provided here will help guide the search for mutants in dfps85D.

Original languageEnglish (US)
Pages (from-to)226-239
Number of pages14
JournalMolecular and cellular biology
Volume11
Issue number1
DOIs
StatePublished - Jan 1991

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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