A global scientific strategy to cure hepatitis B

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs, ICE-HBV Senior Advisors

Research output: Contribution to journalComment/debate

15 Citations (Scopus)

Abstract

Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

Original languageEnglish (US)
Pages (from-to)545-558
Number of pages14
JournalThe Lancet Gastroenterology and Hepatology
Volume4
Issue number7
DOIs
StatePublished - Jul 2019

Fingerprint

Hepatitis B
Hepatitis B virus
Virus Diseases
Chronic Hepatitis B
Circular DNA
Research
Malaria
Tuberculosis
Referral and Consultation
Public Health
Research Personnel
HIV

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs, & ICE-HBV Senior Advisors (2019). A global scientific strategy to cure hepatitis B. The Lancet Gastroenterology and Hepatology, 4(7), 545-558. https://doi.org/10.1016/S2468-1253(19)30119-0
Members of the ICE-HBV Working Groups ; ICE-HBV Stakeholders Group Chairs ; ICE-HBV Senior Advisors. / A global scientific strategy to cure hepatitis B. In: The Lancet Gastroenterology and Hepatology. 2019 ; Vol. 4, No. 7. pp. 545-558.
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abstract = "Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.",
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Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors 2019, 'A global scientific strategy to cure hepatitis B', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. 545-558. https://doi.org/10.1016/S2468-1253(19)30119-0

A global scientific strategy to cure hepatitis B. / Members of the ICE-HBV Working Groups; ICE-HBV Stakeholders Group Chairs; ICE-HBV Senior Advisors.

In: The Lancet Gastroenterology and Hepatology, Vol. 4, No. 7, 07.2019, p. 545-558.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - A global scientific strategy to cure hepatitis B

AU - Members of the ICE-HBV Working Groups

AU - ICE-HBV Stakeholders Group Chairs

AU - ICE-HBV Senior Advisors

AU - Revill, Peter A.

AU - Chisari, Francis V.

AU - Block, Joan M.

AU - Dandri, Maura

AU - Gehring, Adam J.

AU - Guo, Haitao

AU - Hu, Jianming

AU - Kramvis, Anna

AU - Lampertico, Pietro

AU - Janssen, Harry L.A.

AU - Levrero, Massimo

AU - Li, Wenhui

AU - Liang, T. Jake

AU - Lim, Seng Gee

AU - Lu, Fengmin

AU - Penicaud, M. Capucine

AU - Tavis, John E.

AU - Thimme, Robert

AU - Arbuthnot, Patrick

AU - Boonstra, Andre

AU - Chang, Kyong Mi

AU - Chen, Per Jei

AU - Glebe, Dieter

AU - Guidotti, Luca G.

AU - Fellay, Jacques

AU - Ferrari, Carlo

AU - Jansen, Louis

AU - Lau, Daryl T.Y.

AU - Lok, Anna S.

AU - Maini, Mala K.

AU - Mason, William

AU - Matthews, Gail

AU - Paraskevis, Dimitrios

AU - Petersen, Jörg

AU - Rehermann, Barbara

AU - Shin, Eui Cheol

AU - Thompson, Alex

AU - van Bömmel, Florian

AU - Wang, Fu Sheng

AU - Watashi, Koichi

AU - Yang, Hung Chih

AU - Yuan, Zhenghong

AU - Yuen, Man Fung

AU - Block, Timothy

AU - Miller, Veronica

AU - Protzer, Ulrike

AU - Bréchot, Christian

AU - Locarnini, Stephen

AU - Peters, Marion G.

AU - Schinazi, Raymond F.

PY - 2019/7

Y1 - 2019/7

N2 - Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

AB - Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

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U2 - 10.1016/S2468-1253(19)30119-0

DO - 10.1016/S2468-1253(19)30119-0

M3 - Comment/debate

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AN - SCOPUS:85066415366

VL - 4

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EP - 558

JO - The Lancet Gastroenterology and Hepatology

JF - The Lancet Gastroenterology and Hepatology

SN - 2468-1253

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ER -

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs, ICE-HBV Senior Advisors. A global scientific strategy to cure hepatitis B. The Lancet Gastroenterology and Hepatology. 2019 Jul;4(7):545-558. https://doi.org/10.1016/S2468-1253(19)30119-0