A high-legume low-glycemic index diet reduces fasting plasma leptin in middle-aged insulin-resistant and-sensitive men

Z. Zhang, E. Lanza, A. C. Ross, P. S. Albert, N. H. Colburn, M. J. Rovine, D. Bagshaw, J. S. Ulbrecht, T. J. Hartman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fasting leptin and ghrelin levels were measured in 36 insulin-sensitive (IS) and 28 insulin-resistant (IR) men who consumed a legume-enriched low-glycemic index (LG) diet or healthy American (HA) diet in a randomly ordered cross-over feeding study consisting of two 4-week periods. Weight remained stable over the entire study. Fasting plasma leptin was significantly reduced from pre-study levels by both the LG (18.8%, P<0.001) and HA (16.1%, P<0.001) diets, whereas fasting ghrelin did not change. By subgroup analysis according to prestudy insulin status, leptin was reduced in IR subjects after both the LG (17.1%, P<0.01) and the HA (33.3%, P<0.001) diets, whereas IS subjects responded only after the LG diet (23.1%, P<0.01). Thus, a legume-rich LG index diet may be a beneficial strategy for reducing circulating leptin concentrations, even under conditions of weight maintenance.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number3
DOIs
StatePublished - Mar 2011

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Zhang, Z., Lanza, E., Ross, A. C., Albert, P. S., Colburn, N. H., Rovine, M. J., Bagshaw, D., Ulbrecht, J. S., & Hartman, T. J. (2011). A high-legume low-glycemic index diet reduces fasting plasma leptin in middle-aged insulin-resistant and-sensitive men. European Journal of Clinical Nutrition, 65(3), 415-418. https://doi.org/10.1038/ejcn.2010.273