A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety

Jennifer M. McDermott, Koraly Elisa Perez-Edgar, Heather A. Henderson, Andrea Chronis-Tuscano, Daniel S. Pine, Nathan A. Fox

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Background: Behaviorally inhibited (BI) children who also exhibit enhanced response monitoring might be at particularly high risk for anxiety disorders. The current study tests the hypothesis that response monitoring, as manifest in the error-related negativity (ERN), moderates the association between BI and anxiety. Methods: Participants (n = 113; 73 male) assessed for early-childhood BI were re-assessed as adolescents with a clinical interview and a flanker paradigm that generated behavioral data and event-related potentials (ERPs). Risk for anxiety disorders in adolescents was examined as a function of childhood-BI status and adolescent performance on the flanker paradigm. Results: Adolescents with childhood BI displayed ERP evidence of enhanced response monitoring, manifest as large ERNs. The ERN moderated the relationship between early BI and later clinically significant disorders. Conclusions: Physiological measures of response monitoring might moderate associations between early-childhood BI and risk for psychopathology. The subset of children with BI and enhanced response monitoring might face greater risk for later-life clinical anxiety than children with either BI or enhanced response monitoring alone.

Original languageEnglish (US)
Pages (from-to)445-448
Number of pages4
JournalBiological Psychiatry
Volume65
Issue number5
DOIs
StatePublished - Mar 1 2009

Fingerprint

Anxiety
Anxiety Disorders
Evoked Potentials
Psychopathology
Interviews
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

McDermott, Jennifer M. ; Perez-Edgar, Koraly Elisa ; Henderson, Heather A. ; Chronis-Tuscano, Andrea ; Pine, Daniel S. ; Fox, Nathan A. / A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety. In: Biological Psychiatry. 2009 ; Vol. 65, No. 5. pp. 445-448.
@article{ef810bbc3e16463faaa8937f4304d7dc,
title = "A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety",
abstract = "Background: Behaviorally inhibited (BI) children who also exhibit enhanced response monitoring might be at particularly high risk for anxiety disorders. The current study tests the hypothesis that response monitoring, as manifest in the error-related negativity (ERN), moderates the association between BI and anxiety. Methods: Participants (n = 113; 73 male) assessed for early-childhood BI were re-assessed as adolescents with a clinical interview and a flanker paradigm that generated behavioral data and event-related potentials (ERPs). Risk for anxiety disorders in adolescents was examined as a function of childhood-BI status and adolescent performance on the flanker paradigm. Results: Adolescents with childhood BI displayed ERP evidence of enhanced response monitoring, manifest as large ERNs. The ERN moderated the relationship between early BI and later clinically significant disorders. Conclusions: Physiological measures of response monitoring might moderate associations between early-childhood BI and risk for psychopathology. The subset of children with BI and enhanced response monitoring might face greater risk for later-life clinical anxiety than children with either BI or enhanced response monitoring alone.",
author = "McDermott, {Jennifer M.} and Perez-Edgar, {Koraly Elisa} and Henderson, {Heather A.} and Andrea Chronis-Tuscano and Pine, {Daniel S.} and Fox, {Nathan A.}",
year = "2009",
month = "3",
day = "1",
doi = "10.1016/j.biopsych.2008.10.043",
language = "English (US)",
volume = "65",
pages = "445--448",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "5",

}

A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety. / McDermott, Jennifer M.; Perez-Edgar, Koraly Elisa; Henderson, Heather A.; Chronis-Tuscano, Andrea; Pine, Daniel S.; Fox, Nathan A.

In: Biological Psychiatry, Vol. 65, No. 5, 01.03.2009, p. 445-448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety

AU - McDermott, Jennifer M.

AU - Perez-Edgar, Koraly Elisa

AU - Henderson, Heather A.

AU - Chronis-Tuscano, Andrea

AU - Pine, Daniel S.

AU - Fox, Nathan A.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background: Behaviorally inhibited (BI) children who also exhibit enhanced response monitoring might be at particularly high risk for anxiety disorders. The current study tests the hypothesis that response monitoring, as manifest in the error-related negativity (ERN), moderates the association between BI and anxiety. Methods: Participants (n = 113; 73 male) assessed for early-childhood BI were re-assessed as adolescents with a clinical interview and a flanker paradigm that generated behavioral data and event-related potentials (ERPs). Risk for anxiety disorders in adolescents was examined as a function of childhood-BI status and adolescent performance on the flanker paradigm. Results: Adolescents with childhood BI displayed ERP evidence of enhanced response monitoring, manifest as large ERNs. The ERN moderated the relationship between early BI and later clinically significant disorders. Conclusions: Physiological measures of response monitoring might moderate associations between early-childhood BI and risk for psychopathology. The subset of children with BI and enhanced response monitoring might face greater risk for later-life clinical anxiety than children with either BI or enhanced response monitoring alone.

AB - Background: Behaviorally inhibited (BI) children who also exhibit enhanced response monitoring might be at particularly high risk for anxiety disorders. The current study tests the hypothesis that response monitoring, as manifest in the error-related negativity (ERN), moderates the association between BI and anxiety. Methods: Participants (n = 113; 73 male) assessed for early-childhood BI were re-assessed as adolescents with a clinical interview and a flanker paradigm that generated behavioral data and event-related potentials (ERPs). Risk for anxiety disorders in adolescents was examined as a function of childhood-BI status and adolescent performance on the flanker paradigm. Results: Adolescents with childhood BI displayed ERP evidence of enhanced response monitoring, manifest as large ERNs. The ERN moderated the relationship between early BI and later clinically significant disorders. Conclusions: Physiological measures of response monitoring might moderate associations between early-childhood BI and risk for psychopathology. The subset of children with BI and enhanced response monitoring might face greater risk for later-life clinical anxiety than children with either BI or enhanced response monitoring alone.

UR - http://www.scopus.com/inward/record.url?scp=59249085624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59249085624&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2008.10.043

DO - 10.1016/j.biopsych.2008.10.043

M3 - Article

C2 - 19108817

AN - SCOPUS:59249085624

VL - 65

SP - 445

EP - 448

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -