A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

David J. Vandenbergh; Antonio M. Persico; George R. Uhl

doi:10.1016/0169-328X(92)90165-8

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

David J. Vandenbergh, Antonio M. Persico, George R. Uhl

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3′ untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Molecular Brain Research
Volume	15
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(92)90165-8
State	Published - Sep 1992

All Science Journal Classification (ASJC) codes

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(92)90165-8

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abstract = "We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3′ untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.",

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AB - We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function. The cDNA predicts reduced glycosylation of the protein with respect to the rat transporter, as well as a novel repetitive element in the 3′ untranslated region of the cDNA. A TaqI RFLP is also reported that shows a race-specific difference in allelic frequencies.

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A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

Abstract

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