A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies

Zhou Li, Guanhua Deng, Zhe Li, Sherman Xuegang Xin, Song Duan, Maoying Lan, Sa Zhang, Yixin Gao, Jun He, Songtao Zhang, Hongming Tang, Weiwei Wang, Shuai Han, Qing X. Yang, Ling Zhuang, Jiani Hu, Feng Liu

Research output: Contribution to journalArticle

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Abstract

Purpose: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. Methods: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole ColeCole model. Results: The median permittivity and conductivity for the malignant tissue sample were 79.3 and0.881 S/m at 128 MHz, which were 14.6% and 17.0% higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). Conclusions: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.

Original languageEnglish (US)
Pages (from-to)5991-5997
Number of pages7
JournalMedical Physics
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2016

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Neoplasms
Magnetic Resonance Spectroscopy
Tomography
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Li, Zhou ; Deng, Guanhua ; Li, Zhe ; Xin, Sherman Xuegang ; Duan, Song ; Lan, Maoying ; Zhang, Sa ; Gao, Yixin ; He, Jun ; Zhang, Songtao ; Tang, Hongming ; Wang, Weiwei ; Han, Shuai ; Yang, Qing X. ; Zhuang, Ling ; Hu, Jiani ; Liu, Feng. / A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies. In: Medical Physics. 2016 ; Vol. 43, No. 11. pp. 5991-5997.
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title = "A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies",
abstract = "Purpose: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. Methods: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole ColeCole model. Results: The median permittivity and conductivity for the malignant tissue sample were 79.3 and0.881 S/m at 128 MHz, which were 14.6{\%} and 17.0{\%} higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). Conclusions: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.",
author = "Zhou Li and Guanhua Deng and Zhe Li and Xin, {Sherman Xuegang} and Song Duan and Maoying Lan and Sa Zhang and Yixin Gao and Jun He and Songtao Zhang and Hongming Tang and Weiwei Wang and Shuai Han and Yang, {Qing X.} and Ling Zhuang and Jiani Hu and Feng Liu",
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Li, Z, Deng, G, Li, Z, Xin, SX, Duan, S, Lan, M, Zhang, S, Gao, Y, He, J, Zhang, S, Tang, H, Wang, W, Han, S, Yang, QX, Zhuang, L, Hu, J & Liu, F 2016, 'A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies', Medical Physics, vol. 43, no. 11, pp. 5991-5997. https://doi.org/10.1118/1.4964460

A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies. / Li, Zhou; Deng, Guanhua; Li, Zhe; Xin, Sherman Xuegang; Duan, Song; Lan, Maoying; Zhang, Sa; Gao, Yixin; He, Jun; Zhang, Songtao; Tang, Hongming; Wang, Weiwei; Han, Shuai; Yang, Qing X.; Zhuang, Ling; Hu, Jiani; Liu, Feng.

In: Medical Physics, Vol. 43, No. 11, 01.11.2016, p. 5991-5997.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A large-scale measurement of dielectric properties of normal and malignant colorectal tissues obtained from cancer surgeries at Larmor frequencies

AU - Li, Zhou

AU - Deng, Guanhua

AU - Li, Zhe

AU - Xin, Sherman Xuegang

AU - Duan, Song

AU - Lan, Maoying

AU - Zhang, Sa

AU - Gao, Yixin

AU - He, Jun

AU - Zhang, Songtao

AU - Tang, Hongming

AU - Wang, Weiwei

AU - Han, Shuai

AU - Yang, Qing X.

AU - Zhuang, Ling

AU - Hu, Jiani

AU - Liu, Feng

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Purpose: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. Methods: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole ColeCole model. Results: The median permittivity and conductivity for the malignant tissue sample were 79.3 and0.881 S/m at 128 MHz, which were 14.6% and 17.0% higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). Conclusions: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.

AB - Purpose: Knowledge of dielectric properties of malignant human tissues is necessary for the recently developed magnetic resonance (MR) technique called MR electrical property tomography. This technique may be used in early tumor detection based on the obvious differentiation of the dielectric properties between normal and malignant tissues. However, the dielectric properties of malignant human tissues in the scale of the Larmor frequencies are not completely available in the literature. In this study, the authors focused only on the dielectric properties of colorectal tumor tissue. Methods: The dielectric properties of 504 colorectal malignant samples excised from 85 patients in the scale of the Larmor frequencies were measured using the precision open-ended coaxial probe method. The obtained complex-permittivity data were fitted to the single-pole ColeCole model. Results: The median permittivity and conductivity for the malignant tissue sample were 79.3 and0.881 S/m at 128 MHz, which were 14.6% and 17.0% higher, respectively, than those of normal tissue samples. Significant differences between normal and malignant tissues were found for the dielectric properties (p < 0.05). Conclusions: Experimental results indicated that the dielectric properties were significantly different between normal and malignant tissues for colorectal tissue. This large-scale clinical measurement provides more subtle base data to validate the technique of MR electrical property tomography.

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