A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family

C. X. Ma, M. Lin, R. C. Littell, T. Yin, Rongling Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dominant markers have been commonly used in mapping quantitative trait loci (QTLs) in outcrossing species, in which not much prior genome information is available. But the dominant nature of these markers may lead to reduced QTL mapping precision and power. A new statistical method is proposed to incorporate growth laws into a QTL mapping framework, under which the use of the efficiency of dominant markers can be increased. This new method can be used to identify specific QTLs affecting differentiation in growth trajectories, and further estimate the timing of a QTL to turn on, or turn off, affecting growth during the entire ontogeny of a species. Using this method based on dominant markers we have successfully mapped a QTL for stem height growth trajectories to a linkage group in a forest tree. The implications of this method for the understanding of the genetic architecture of growth using dominant markers are discussed.

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
JournalTheoretical and Applied Genetics
Volume108
Issue number4
DOIs
StatePublished - Feb 1 2004

Fingerprint

Quantitative Trait Loci
trajectories
quantitative trait loci
Growth
outcrossing
forest trees
linkage groups
ontogeny
statistical analysis
methodology
Genome
stems
genome

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science
  • Genetics

Cite this

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A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family. / Ma, C. X.; Lin, M.; Littell, R. C.; Yin, T.; Wu, Rongling.

In: Theoretical and Applied Genetics, Vol. 108, No. 4, 01.02.2004, p. 699-705.

Research output: Contribution to journalArticle

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