A likelihood approach for mapping growth trajectories using dominant markers in a phase-unknown full-sib family

C. X. Ma, M. Lin, R. C. Littell, T. Yin, R. Wu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Dominant markers have been commonly used in mapping quantitative trait loci (QTLs) in outcrossing species, in which not much prior genome information is available. But the dominant nature of these markers may lead to reduced QTL mapping precision and power. A new statistical method is proposed to incorporate growth laws into a QTL mapping framework, under which the use of the efficiency of dominant markers can be increased. This new method can be used to identify specific QTLs affecting differentiation in growth trajectories, and further estimate the timing of a QTL to turn on, or turn off, affecting growth during the entire ontogeny of a species. Using this method based on dominant markers we have successfully mapped a QTL for stem height growth trajectories to a linkage group in a forest tree. The implications of this method for the understanding of the genetic architecture of growth using dominant markers are discussed.

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
JournalTheoretical and Applied Genetics
Volume108
Issue number4
DOIs
StatePublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science
  • Genetics

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