A mass spectrometric solution to the address problem of combinatorial libraries

Christopher L. Brummel, Irene N.W. Lee, Ying Zhou, Stephen J. Benkovic, Nicholas Winograd

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

The molecular weights of femtomole quantities of small peptides attached to polystyrene beads have been determined with imaging time-of-flight secondary ion mass spectrometry. The analysis is made possible by the selective clipping of the bond linking the peptide to a bead with trifluoroacetic acid vapor before the secondary ion mass spectrometry assay. The approach can be applied to large numbers of 30- to 60-micrometer polystyrene beads for the direct characterization of massive combinatorial libraries.

Original languageEnglish (US)
Pages (from-to)399-402
Number of pages4
JournalScience
Volume264
Issue number5157
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'A mass spectrometric solution to the address problem of combinatorial libraries'. Together they form a unique fingerprint.

Cite this