A mathematical model of idiopathic pulmonary fibrosis

Wenrui Hao, Clay Marsh, Avner Friedman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology, and life expectancy of 3-5 years after diagnosis. The incidence rate in the United States is estimated as high as 15 per 100,000 persons per year. The disease is characterized by repeated injury to the alveolar epithelium, resulting in inflammation and deregulated repair, leading to scarring of the lung tissue, resulting in progressive dyspnea and hypoxemia. The disease has no cure, although new drugs are in clinical trials and two agents have been approved for use by the FDA. In the present paper we develop a mathematical model based on the interactions among cells and proteins that are involved in the progression of the disease. The model simulations are shown to be in agreement with available lung tissue data of human patients. The model can be used to explore the efficacy of potential drugs.

Original languageEnglish (US)
Article numbere0135097
JournalPloS one
Volume10
Issue number9
DOIs
StatePublished - Sep 8 2015

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Idiopathic Pulmonary Fibrosis
fibrosis
Theoretical Models
mathematical models
lungs
Mathematical models
Lung
new drugs
dyspnea
Tissue
Life Expectancy
disease course
Cell Communication
Pharmaceutical Preparations
Dyspnea
Cicatrix
etiology
Disease Progression
hypoxia
clinical trials

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Hao, Wenrui ; Marsh, Clay ; Friedman, Avner. / A mathematical model of idiopathic pulmonary fibrosis. In: PloS one. 2015 ; Vol. 10, No. 9.
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A mathematical model of idiopathic pulmonary fibrosis. / Hao, Wenrui; Marsh, Clay; Friedman, Avner.

In: PloS one, Vol. 10, No. 9, e0135097, 08.09.2015.

Research output: Contribution to journalArticle

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