A matrix computational approach to kinesin neck linker extension

John Hughes, William O. Hancock, John Fricks

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Kinesin stepping requires both tethered diffusion of the free head and conformational changes driven by the chemical state of the motor. We present a numerical method using matrix representations of approximating Markov chains and renewal theory to compute important experimental quantities for models that include both tethered diffusion and chemical transitions. Explicitly modeling the tethered diffusion allows for exploration of the model under perturbation of the neck linker; comparisons are made between the computed models and in vitro assays.

Original languageEnglish (US)
Pages (from-to)181-194
Number of pages14
JournalJournal of Theoretical Biology
Volume269
Issue number1
DOIs
StatePublished - Jan 21 2011

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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