TY - GEN
T1 - A mechano-hydraulic model of intracranial pressure dynamics
AU - Evans, D.
AU - Drapaca, C.
AU - Cusumano, J. P.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The brain is a multi-phase mixture of cerebrospinal fluid (CSF), vasculature, and brain cells. The intracranial pressure (ICP) of the CSF can be monitored to assess patients suffering from serious neurological disorders, such as hydrocephalus and traumatic brain injury. However, the only reliable way to measure ICP is to drill a hole through the skull to insert a pressure sensor inside the brain. Therefore, it is necessary to create accurate mathematical models that couple the temporal dynamics of ICP with clinically-observable physiological parameters that can be measured non-invasively. In this paper, we present a new mechano-hydraulic mathematical model that allows one to study the dynamics arising from the coupling between the mechanics of brain, CSF circulation, and cerebral blood flow. We will study the dynamics of the model and examine domains of stability.
AB - The brain is a multi-phase mixture of cerebrospinal fluid (CSF), vasculature, and brain cells. The intracranial pressure (ICP) of the CSF can be monitored to assess patients suffering from serious neurological disorders, such as hydrocephalus and traumatic brain injury. However, the only reliable way to measure ICP is to drill a hole through the skull to insert a pressure sensor inside the brain. Therefore, it is necessary to create accurate mathematical models that couple the temporal dynamics of ICP with clinically-observable physiological parameters that can be measured non-invasively. In this paper, we present a new mechano-hydraulic mathematical model that allows one to study the dynamics arising from the coupling between the mechanics of brain, CSF circulation, and cerebral blood flow. We will study the dynamics of the model and examine domains of stability.
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U2 - 10.1007/978-3-319-41351-8_16
DO - 10.1007/978-3-319-41351-8_16
M3 - Conference contribution
AN - SCOPUS:84990046573
SN - 9783319413501
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 111
EP - 118
BT - Mechanics of Biological Systems and Materials - Proceedings of the 2016 Annual Conference on Experimental and Applied Mechanics
A2 - Korach, Chad S.
A2 - Tekalur, Srinivasan Arjun
A2 - Zavattieri, Pablo
PB - Springer New York LLC
T2 - Annual Conference and Exposition on Experimental and Applied Mechanics, 2016
Y2 - 6 June 2016 through 9 June 2016
ER -