A metagenomic survey of microbes in honey bee colony collapse disorder

Diana L. Cox-Foster, Sean Conlan, Edward C. Holmes, Gustavo Palacios, Jay D. Evans, Nancy A. Moran, Phenix Lan Quan, Thomas Briese, Mady Hornig, David M. Geiser, Vince Martinson, Dennis VanEngelsdorp, Abby L. Kalkstein, Andrew Drysdale, Jeffrey Hui, Junhui Zhai, Liwang Cui, Stephen K. Hutchison, Jan Fredrik Simons, Michael EgholmJeffery S. Pettis, W. Ian Lipkin

Research output: Contribution to journalArticle

1096 Citations (Scopus)

Abstract

In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. The observation that irradiated combs from affected colonies can be repopulated with naive bees suggests that infection may contribute to CCD. We used an unbiased metagenomic approach to survey microflora in CCD hives, normal hives, and imported royal jelly. Candidate pathogens were screened for significance of association with CCD by the examination of samples collected from several sites over a period of 3 years. One organism, Israeli acute paralysis virus of bees, was strongly correlated with CCD.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalScience
Volume318
Issue number5848
DOIs
StatePublished - Oct 12 2007

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Colony Collapse
Metagenomics
Honey
Bees
Urticaria
Dicistroviridae
Beekeeping
Comb and Wattles
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • General

Cite this

Cox-Foster, D. L., Conlan, S., Holmes, E. C., Palacios, G., Evans, J. D., Moran, N. A., ... Lipkin, W. I. (2007). A metagenomic survey of microbes in honey bee colony collapse disorder. Science, 318(5848), 283-287. https://doi.org/10.1126/science.1146498
Cox-Foster, Diana L. ; Conlan, Sean ; Holmes, Edward C. ; Palacios, Gustavo ; Evans, Jay D. ; Moran, Nancy A. ; Quan, Phenix Lan ; Briese, Thomas ; Hornig, Mady ; Geiser, David M. ; Martinson, Vince ; VanEngelsdorp, Dennis ; Kalkstein, Abby L. ; Drysdale, Andrew ; Hui, Jeffrey ; Zhai, Junhui ; Cui, Liwang ; Hutchison, Stephen K. ; Simons, Jan Fredrik ; Egholm, Michael ; Pettis, Jeffery S. ; Lipkin, W. Ian. / A metagenomic survey of microbes in honey bee colony collapse disorder. In: Science. 2007 ; Vol. 318, No. 5848. pp. 283-287.
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author = "Cox-Foster, {Diana L.} and Sean Conlan and Holmes, {Edward C.} and Gustavo Palacios and Evans, {Jay D.} and Moran, {Nancy A.} and Quan, {Phenix Lan} and Thomas Briese and Mady Hornig and Geiser, {David M.} and Vince Martinson and Dennis VanEngelsdorp and Kalkstein, {Abby L.} and Andrew Drysdale and Jeffrey Hui and Junhui Zhai and Liwang Cui and Hutchison, {Stephen K.} and Simons, {Jan Fredrik} and Michael Egholm and Pettis, {Jeffery S.} and Lipkin, {W. Ian}",
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Cox-Foster, DL, Conlan, S, Holmes, EC, Palacios, G, Evans, JD, Moran, NA, Quan, PL, Briese, T, Hornig, M, Geiser, DM, Martinson, V, VanEngelsdorp, D, Kalkstein, AL, Drysdale, A, Hui, J, Zhai, J, Cui, L, Hutchison, SK, Simons, JF, Egholm, M, Pettis, JS & Lipkin, WI 2007, 'A metagenomic survey of microbes in honey bee colony collapse disorder', Science, vol. 318, no. 5848, pp. 283-287. https://doi.org/10.1126/science.1146498

A metagenomic survey of microbes in honey bee colony collapse disorder. / Cox-Foster, Diana L.; Conlan, Sean; Holmes, Edward C.; Palacios, Gustavo; Evans, Jay D.; Moran, Nancy A.; Quan, Phenix Lan; Briese, Thomas; Hornig, Mady; Geiser, David M.; Martinson, Vince; VanEngelsdorp, Dennis; Kalkstein, Abby L.; Drysdale, Andrew; Hui, Jeffrey; Zhai, Junhui; Cui, Liwang; Hutchison, Stephen K.; Simons, Jan Fredrik; Egholm, Michael; Pettis, Jeffery S.; Lipkin, W. Ian.

In: Science, Vol. 318, No. 5848, 12.10.2007, p. 283-287.

Research output: Contribution to journalArticle

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AU - Conlan, Sean

AU - Holmes, Edward C.

AU - Palacios, Gustavo

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AU - Moran, Nancy A.

AU - Quan, Phenix Lan

AU - Briese, Thomas

AU - Hornig, Mady

AU - Geiser, David M.

AU - Martinson, Vince

AU - VanEngelsdorp, Dennis

AU - Kalkstein, Abby L.

AU - Drysdale, Andrew

AU - Hui, Jeffrey

AU - Zhai, Junhui

AU - Cui, Liwang

AU - Hutchison, Stephen K.

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AU - Pettis, Jeffery S.

AU - Lipkin, W. Ian

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Cox-Foster DL, Conlan S, Holmes EC, Palacios G, Evans JD, Moran NA et al. A metagenomic survey of microbes in honey bee colony collapse disorder. Science. 2007 Oct 12;318(5848):283-287. https://doi.org/10.1126/science.1146498