A method performance evaluation and lessons learned after analyzing more than 5,000 human adipose tissue, serum, and breast milk samples for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs)

D. G. Patterson, W. E. Turner, S. G. Isaacs, L. R. Alexander

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Over the past 5 years, the Centers for Disease Control had analyzed more than 5,000 adipose tissue and serum samples for PCDDs and PCDFs. These samples have been collected under strict protocols for large-scale studies including: 1) The Agent Orange Vietnam Veteran Validation Study; 2) The Missouri Adipose Tissue Study; 3) The Air Force Ranch Hand Study; 4) The NIOSH Worker Study; as well as several smaller studies. Because of our extensive quality assurance program over the years, we have been able to identify several major areas of potential analytical contamination that should be avoided by laboratories performing analyses of biological samples. We also present the results of long-term stability studies of 2378-TCDD in adipose tissue and serum (5-6 years) as well as the stability of PCDDs and PCDFs after they have been extracted from the sample matrix. In addition, we discuss the results of a performance evaluation of our method which includes small interlaboratory studies with other laboratories performing PCDD and PCDF analyses in biological samples.

Original languageEnglish (US)
Pages (from-to)829-836
Number of pages8
JournalChemosphere
Volume20
Issue number7-9
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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