A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters

Puhui Li, Max M. Majireck, Ilia Korboukh, Steven M. Weinreb

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A wide variety of α-diazo-β-ketoesters can be prepared in good overall yields via a two-step sequence involving addition of ethyl lithiodiazoacetate to aliphatic, aromatic, and conjugated aldehydes followed by mild oxidation with the Dess-Martin periodinane.

Original languageEnglish (US)
Pages (from-to)3162-3164
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number19
DOIs
StatePublished - May 5 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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