A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters

Puhui Li, Max M. Majireck, Ilia Korboukh, Steven M. Weinreb

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A wide variety of α-diazo-β-ketoesters can be prepared in good overall yields via a two-step sequence involving addition of ethyl lithiodiazoacetate to aliphatic, aromatic, and conjugated aldehydes followed by mild oxidation with the Dess-Martin periodinane.

Original languageEnglish (US)
Pages (from-to)3162-3164
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number19
DOIs
StatePublished - May 5 2008

Fingerprint

Aldehydes
Oxidation
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Li, Puhui ; Majireck, Max M. ; Korboukh, Ilia ; Weinreb, Steven M. / A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 19. pp. 3162-3164.
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A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters. / Li, Puhui; Majireck, Max M.; Korboukh, Ilia; Weinreb, Steven M.

In: Tetrahedron Letters, Vol. 49, No. 19, 05.05.2008, p. 3162-3164.

Research output: Contribution to journalArticle

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AU - Li, Puhui

AU - Majireck, Max M.

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AU - Weinreb, Steven M.

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