50 Citations (Scopus)

Abstract

We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.

Original languageEnglish (US)
Pages (from-to)53-70
Number of pages18
JournalJournal of Computational Neuroscience
Volume19
Issue number1
DOIs
StatePublished - Aug 1 2005

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Neurons
Seizures
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

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abstract = "We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.",
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A model of the effects of applied electric fields on neuronal synchronization. / Park, Eun Hyoung; Barreto, Ernest; Gluckman, Bruce; Schiff, Steven; So, Paul.

In: Journal of Computational Neuroscience, Vol. 19, No. 1, 01.08.2005, p. 53-70.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A model of the effects of applied electric fields on neuronal synchronization

AU - Park, Eun Hyoung

AU - Barreto, Ernest

AU - Gluckman, Bruce

AU - Schiff, Steven

AU - So, Paul

PY - 2005/8/1

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AB - We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.

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