A model of the endogenous electrical field effect: Can ephaptic transmission cause neuronal synchronization independently?

Zhou Yue, Wei Xile, Lu Meili, Deng Bin, Wang Jiang, Yanqiu Che

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An endogenous electrical field effect, i.e., ephaptic transmission, occurs when an electric field associated with activity occurring in one neuron polarizes the membrane of another neuron. It is well established that field effects occur during pathological conditions, such as epilepsy, but less clear if they play a functional role in the healthy brain. Most of studies put excessive attention on the mechanism of chemical synapse. However, the mechanism of ephaptic transmission is still uncertain. Recently, some physiologic studies speculate that ephaptic transmission can cause neuronal synchronization, such as in teleost Mauthner cells. But this conclusion is not well verified. Here, a model is set up to study the effect of ephasptic transmission to neuronal synchronization independently without any other interactive ways. The role of neuronal heterogeneity to endogenous electrical field effect is also investigated. The simulation results showed that 1) Ephaptic transmission can be responsible for independently inducing neuronal synchronization and the network shows higher synchronicity when the coupling strength increasing; 2) In sufficiently heterogeneous ensembles, increasing coupling strength tends to desynchronize the network.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Chinese Control Conference, CCC 2012
Pages7360-7365
Number of pages6
StatePublished - Dec 1 2012
Event31st Chinese Control Conference, CCC 2012 - Hefei, China
Duration: Jul 25 2012Jul 27 2012

Other

Other31st Chinese Control Conference, CCC 2012
CountryChina
CityHefei
Period7/25/127/27/12

Fingerprint

Synchronization
Neurons
Neuron
Epilepsy
Model
Synapse
Brain
Electric Field
Ensemble
Membrane
Electric fields
Tend
Membranes
Cell
Simulation

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Control and Systems Engineering
  • Applied Mathematics
  • Modeling and Simulation

Cite this

Yue, Z., Xile, W., Meili, L., Bin, D., Jiang, W., & Che, Y. (2012). A model of the endogenous electrical field effect: Can ephaptic transmission cause neuronal synchronization independently? In Proceedings of the 31st Chinese Control Conference, CCC 2012 (pp. 7360-7365). [6391243]
Yue, Zhou ; Xile, Wei ; Meili, Lu ; Bin, Deng ; Jiang, Wang ; Che, Yanqiu. / A model of the endogenous electrical field effect : Can ephaptic transmission cause neuronal synchronization independently?. Proceedings of the 31st Chinese Control Conference, CCC 2012. 2012. pp. 7360-7365
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Yue, Z, Xile, W, Meili, L, Bin, D, Jiang, W & Che, Y 2012, A model of the endogenous electrical field effect: Can ephaptic transmission cause neuronal synchronization independently? in Proceedings of the 31st Chinese Control Conference, CCC 2012., 6391243, pp. 7360-7365, 31st Chinese Control Conference, CCC 2012, Hefei, China, 7/25/12.

A model of the endogenous electrical field effect : Can ephaptic transmission cause neuronal synchronization independently? / Yue, Zhou; Xile, Wei; Meili, Lu; Bin, Deng; Jiang, Wang; Che, Yanqiu.

Proceedings of the 31st Chinese Control Conference, CCC 2012. 2012. p. 7360-7365 6391243.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yue Z, Xile W, Meili L, Bin D, Jiang W, Che Y. A model of the endogenous electrical field effect: Can ephaptic transmission cause neuronal synchronization independently? In Proceedings of the 31st Chinese Control Conference, CCC 2012. 2012. p. 7360-7365. 6391243