Abstract
An endogenous electrical field effect, i.e., ephaptic transmission, occurs when an electric field associated with activity occurring in one neuron polarizes the membrane of another neuron. It is well established that field effects occur during pathological conditions, such as epilepsy, but less clear if they play a functional role in the healthy brain. Most of studies put excessive attention on the mechanism of chemical synapse. However, the mechanism of ephaptic transmission is still uncertain. Recently, some physiologic studies speculate that ephaptic transmission can cause neuronal synchronization, such as in teleost Mauthner cells. But this conclusion is not well verified. Here, a model is set up to study the effect of ephasptic transmission to neuronal synchronization independently without any other interactive ways. The role of neuronal heterogeneity to endogenous electrical field effect is also investigated. The simulation results showed that 1) Ephaptic transmission can be responsible for independently inducing neuronal synchronization and the network shows higher synchronicity when the coupling strength increasing; 2) In sufficiently heterogeneous ensembles, increasing coupling strength tends to desynchronize the network.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of the 31st Chinese Control Conference, CCC 2012 |
| Pages | 7360-7365 |
| Number of pages | 6 |
| State | Published - Dec 1 2012 |
| Event | 31st Chinese Control Conference, CCC 2012 - Hefei, China Duration: Jul 25 2012 → Jul 27 2012 |
Other
| Other | 31st Chinese Control Conference, CCC 2012 |
|---|---|
| Country | China |
| City | Hefei |
| Period | 7/25/12 → 7/27/12 |
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All Science Journal Classification (ASJC) codes
- Computer Science Applications
- Control and Systems Engineering
- Applied Mathematics
- Modeling and Simulation
Cite this
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A model of the endogenous electrical field effect : Can ephaptic transmission cause neuronal synchronization independently? / Yue, Zhou; Xile, Wei; Meili, Lu; Bin, Deng; Jiang, Wang; Che, Yanqiu.
Proceedings of the 31st Chinese Control Conference, CCC 2012. 2012. p. 7360-7365 6391243.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - A model of the endogenous electrical field effect
T2 - Can ephaptic transmission cause neuronal synchronization independently?
AU - Yue, Zhou
AU - Xile, Wei
AU - Meili, Lu
AU - Bin, Deng
AU - Jiang, Wang
AU - Che, Yanqiu
PY - 2012/12/1
Y1 - 2012/12/1
N2 - An endogenous electrical field effect, i.e., ephaptic transmission, occurs when an electric field associated with activity occurring in one neuron polarizes the membrane of another neuron. It is well established that field effects occur during pathological conditions, such as epilepsy, but less clear if they play a functional role in the healthy brain. Most of studies put excessive attention on the mechanism of chemical synapse. However, the mechanism of ephaptic transmission is still uncertain. Recently, some physiologic studies speculate that ephaptic transmission can cause neuronal synchronization, such as in teleost Mauthner cells. But this conclusion is not well verified. Here, a model is set up to study the effect of ephasptic transmission to neuronal synchronization independently without any other interactive ways. The role of neuronal heterogeneity to endogenous electrical field effect is also investigated. The simulation results showed that 1) Ephaptic transmission can be responsible for independently inducing neuronal synchronization and the network shows higher synchronicity when the coupling strength increasing; 2) In sufficiently heterogeneous ensembles, increasing coupling strength tends to desynchronize the network.
AB - An endogenous electrical field effect, i.e., ephaptic transmission, occurs when an electric field associated with activity occurring in one neuron polarizes the membrane of another neuron. It is well established that field effects occur during pathological conditions, such as epilepsy, but less clear if they play a functional role in the healthy brain. Most of studies put excessive attention on the mechanism of chemical synapse. However, the mechanism of ephaptic transmission is still uncertain. Recently, some physiologic studies speculate that ephaptic transmission can cause neuronal synchronization, such as in teleost Mauthner cells. But this conclusion is not well verified. Here, a model is set up to study the effect of ephasptic transmission to neuronal synchronization independently without any other interactive ways. The role of neuronal heterogeneity to endogenous electrical field effect is also investigated. The simulation results showed that 1) Ephaptic transmission can be responsible for independently inducing neuronal synchronization and the network shows higher synchronicity when the coupling strength increasing; 2) In sufficiently heterogeneous ensembles, increasing coupling strength tends to desynchronize the network.
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UR - http://www.scopus.com/inward/citedby.url?scp=84873531209&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84873531209
SN - 9789881563811
SP - 7360
EP - 7365
BT - Proceedings of the 31st Chinese Control Conference, CCC 2012
ER -